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Abstract To investigate the effects of oxytocin combined with epidural anesthesia on the postpartum hemorrhage and the maternal and infant outcomes of primipara with singleton. Methods: A total of 106 primipara with singleton were selected and were divided into observation group (primipara with oxytocin combined with epidural anesthesia) and control group (primipara with epidural anesthesia) according to the random number table from May 2019 to May 2021. The labor time, the pain degree by visual pain scale (VAS), the postpartum hemorrhage volume, the maternal and infant outcomes, and the levels of stress response indexes, such as cortisol (Cor), norepinephrine (NE), and epinephrine (ADR) of the primipara were compared between the two groups. Results: The first, the second, and the total stages of labor of the primipara in the observation group were significantly shorter than those of the primipara in the control group. The VAS scores of the primipara in the observation group during the incubation period and the active period of the first stage of labor, during the second stage of labor, and during the third stage of labor were all significantly lower than those of the primipara in the control group. The blood loss of the primipara in the observation group in postpartum 30min (165.9±14.5ml), 2h (85.0±12.5 ml), or 24h (71.0±9.0 ml) was significantly lower than that (201.3±16.9 ml, 102.1±15.7 ml, or 84.3±12.3 ml) of the primipara in the control group. The levels of Cor, NE, and ADR of the primipara in the observation group when the orifice of the uterus opened to 3cm, the orifice of the uterus opened completely, or the delivery of baby were significantly lower than those of the primipara in the control group. The vaginal delivery rate (77.4%) of the primipara in the observation group was significantly higher than that (56.6%) of the primipara in the control group, while the cesarean section rate, the postpartum hemorrhage rate, the soft birth canal tear rate, and the neonatal asphyxia rate of the primipara in the observation group were significantly lower than those of the primipara in the control group (all P＜0.05). Conclusion: Oxytocin combined with epidural anesthesia used in the delivery of the primipara with singleton is beneficial to shorten the labor stage, reduce the amount of postpartum hemorrhage, and improve the maternal and infant outcomes.
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