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Abstract To explore the influence of transversus abdominis plane (TAP) block combined with general anesthesia during laparoscopic radical resection of endometrial cancer (EC) of patients on the sufentanil dosage and the analgesic effect. Methods: A total of 126 patients who wanted laparoscopic radical resection of EC were enrolled and were divided into two groups (63 cases in each group) according to random number table method from January 2020 to September 2021. The patients in both groups were treated with general anesthesia during operation and the patient controlled intravenous analgesia (PCIA) were given the patients in both groups after operation. TAP block was used for the patients in the observation group. The scores of visual analogue scales (VAS) at 4h, 8h, 12h, and 24h after operation, the awakening time, the first exhaust time, the sufentanil dosage, the times of effective PCIA compression per 24h, the postoperative adverse reactions, the levels of stress response indexes at 12h after operation, such as cortisol (Cor) and blood glucose (Glu), and the interleukin-6 (IL-6) level of the patients were compared between the two groups. Results: The VAS scores of the patients in the observation group at postoperative 4, 8, 12 and 24h were 3.64±0.57 points, 3.05±0.63 points, 2.53±0.58 points, and 1.77±0.49 points, respectively, which were significantly lower than those (4.73±0.62 points, 3.84±0.71 points, 3.11±0.64 points, and 2.42±0.51 points) of the patients in the control group. The awakening time (6.1±1.5min), the recovery time of spontaneous respiration (7.3±2.1min), the times of effective compression of PCIA per 24h (2.5±0.6 times), the postoperative dosage of sufentanil (61.4±1.1μg), the levels of Glu (5.91±1.02mmol/L), Cor (273.54±30.28 μg/L), and IL-6 (170.57±20.68pg/ml), and the total incidence of adverse reactions (4.8%) of the patients in the observation group were significantly lower than those (7.2±2.0min, 10.7±3.2min, 3.6±1.0 times, 64.8±3.5μg, 7.35±0.97mmol/L, 365.27±32.51μg/L, 315.14±25.26pg/ml, and 15.9%) of the patients in the control group (all P＜0.05). Conclusion: TAP block combined general anesthesia is of high postoperative analgesia quality for the patients with EC, which can reduce the postoperative sufentanil dosage, alleviate stress and inflammatory response of the patients, and improve the awakening quality, with certain safety.
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