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| Correlation between the levels of serum anti-mullerian hormone and integrin β-1 of pregnant women with preeclampsia during the second and the third trimester of pregnancy and their uterine spiral artery blood flow parameters and vascular endothelial cell injury indictors |
| Taizhou People's Hospital, Taizhou, Jiangsu Province, 225300 |
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Abstract To investigate the correlation of the levels of the serum anti-Müllerian hormone (AMH) and integrin β1 (ITGβ-1) of pregnant women with preeclampsia during the second and the third trimester of pregnancy and their uterine spiral artery blood flow parameters and vascular endothelial cell (VEC) injury indictors. Methods: 96 pregnant women with preeclampsia during the second and the third trimester of pregnancy were selected in observation group and another 96 healthy pregnant women were selected in control group from March 2019 to March 2021. The serum AMH and ITGβ-1 levels, and the values of uterine spiral artery blood flow parameters, such as PI, RI, and S/D, and the levels of endothelial progenitor cells (EPCs) and angiogenic T cells (Tang) of the women in both groups were measured, and the correlation of which each other was analyzed. Results: The levels of AMH (1.62±0.15 ng/ml) and ITGβ-1 (0.05±0.02) of the women in the observation group were significantly lower than those (2.44±0.17 ng/ml and 0.18±0.03) of the women in the control group. The values of the uterine spiral artery blood flow parameters of the women in the observation group were significantly higher than those of the women in the control group. The levels of EPCs (0.08±0.03%) and Tang (47.31±8.57%) of the women in the observation group were significantly lower than those (0.16±0.05 % and 53.61±7.95%) of the women in the control group (all P<0.05). The levels of AMH and ITGβ-1 of the women were negatively correlated with their uterine spiral artery blood flow parameters values, and were positively correlated with their VEC injury indexes values (all P<0.05). Conclusion: The levels of serum AMH and
ITGβ-1 of the pregnant women with preeclampsia during the second and the third trimester of pregnancy change abnormally, which are correlated with their uterine spiral artery blood flow parameters and their VEC injury.
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