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Abstract To explore the changes of coagulation function indicators and its clinical significance of pregnant women with pregnancy induce hypertension syndrome (PIHS). Methods: A total of 100 pregnant women with PIHS were selected in observation group, and another 100 healthy pregnant women were selected in control group from January 2019 to December 2019. The women in the observation group were divided into group A (45 cases with gestational hypertension), group B (30 cases with preeclampsia), and group C (25 cases with severe preeclampsia). The values of the prothrombin time (PT), thrombin time (TT), activated partial thrombin time (APTT), and the levels of fibrinogen (FIB), D-dimer (D-D) of the women during 8-12 gestational weeks, 20-27 gestational weeks, 28-32 gestational weeks were detected and were compared between the two groups. The correlation between the blood coagulation function index of the women and the severity of their PIHS was analyzed. Results: There were no significant differences in the values of PT, TT, APTT, FIB, and D-D of the women during the first trimester of pregnancy between the observation group and the control group (P＞0.05). The values of PT, TT and APTT of the women in the observation group during the second and third trimester of pregnancy were significantly lower than those during the first trimester of pregnancy, and which of the women were significantly lower than those of the women in the control group during the second and third trimester of pregnancy. The FIB and D-D levels of the women in the observation group during the second and third trimester of pregnancy were significantly higher than those during the first trimester of pregnancy, and which of the women were significantly higher than those of the women in the control group during the second and third trimester of pregnancy. The values of PT, TT, and APTT of the women in the observation group during the third trimester of pregnancy were significantly lower than those during the second trimester of pregnancy, and the FIB and D-D levels of the women in the observation group during the third trimester of pregnancy were significantly higher. During the second and third trimester of pregnancy, the values of PT, TT, and APTT of the women in group A, B, and C had decreased gradually, while the FIB and D-D levels had increased gradually (all P<0.05). The values of PT, TT, and APTT of the women were negatively correlated with their PIHS, and the FIB and D-D levels of the women were positively correlated with their PIHS (all P<0.01). Conclusion: The coagulation function indexes of the women with PIHS during the second and third trimester of pregnancy change abnormally, and which of the women are correlated with the severity of their PIHS.
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