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| The levels of glycosylated hemoglobin and adiponectin of pregnant women with gestational diabetes mellitus and their influence on the maternal and neonatal outcomes |
| The First People's Hospital of Yibin City, Sichuan Province, 644000 |
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Abstract To explore the levels of glycosylated hemoglobin (HbA1c) and adiponectin (ADP) of pregnant women with gestational diabetes mellitus (GDM), and to study their influence on the maternal and neonatal outcomes. Methods: The clinical data of pregnant women who received antenatal care and gave birth between June 2018 and June 2020 were collected, which included 108 women with GDM in observation group and 98 healthy pregnant women in control group. The HbA1c and ADP levels, and the pregnancy outcomes of the women were compared between the two groups. The incidence of adverse pregnancy outcomes was compared among the women with different HbA1c and ADP levels in the observation group. The influence of the HbA1c and ADP levels of the women on their adverse pregnancy outcomes was analyzed by Logistic regression model. Results: The levels of blood glucose and fasting insulin of the women in the observation group were significantly higher than those of the women in the control group. The HbA1 value (7.64±1.25 %) of the women in the observation group was significantly higher than that (5.14±0.81%) of the women in the control group. The level of ADP (7.85±0.94 ng/L) of the women in the observation group was significantly lower than that (12.16±1.47 ng/L) of the women in the control group. The incidences of premature rupture of membranes (18.5%), polyhydramnios (20.4%), and meconium-staining of amniotic fluid (13.9%) of the women in the observation group were significantly higher than those (8.2%, 6.1%, and 3.1%) of the women in the control group. The incidences of preterm birth (14.8%), macrosomia (23.2%), and fetal distress (10.2%) in the observation group were significantly higher than those (5.1%, 5.1%, and 2.0%) in the control group (all P<0.05). In the observation group, the incidences of adverse pregnancy outcomes and neonatal adverse outcomes of the pregnant women with HbA1 value≥6.0% and ADP level <10mg/L were significantly higher than those of the pregnant women with HbA1 value <6.0% and ADP level≥10mg/L (P<0.05). Regression analysis showed that the HbA1 value ≥6.0% and the ADP level＜10mg/L of the women with GDM were the influencing factors of their adverse pregnancy outcomes (P<0.05). Conclusion: The pregnant women with GDM have abnormal levels of HbA1c and ADP with the increase of adverse pregnancy outcomes risk, which suggesting that the levels of HbA1c and ADP should be paid attention to in clinic for guiding the clinical interventions and reducing the incidence of adverse pregnancy.
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