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| Correlation of sex hormone level and thrombin activatable fibrinolysis inhibitor gene polymorphisms of the women with threatened abortion during the first trimester of pregnancy and their pregnancy outcomes |
| Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, 201599 |
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Abstract To investigate the correlation of thrombin activatable fibrinolysis inhibitor (TAFI) gene polymorphism and serum sex hormone level of the women with threatened abortion during the first trimester of pregnancy and their pregnancy outcomes. Methods: The clinical data of 113 women with threatened abortion during the first trimester of pregnancy (in study group) and another 96 normal pregnancy women (in control group) from 2018 to 2020 were collected. Genotyping of TAFI1040C/T polymorphisms were detected by allele-specific polymerase chain reaction (AS-PCR). The levels of serum sex hormones were detected by chemiluminescence immunoassay. The women in the study group were further divided in group A (women with inevitable abortion) and group B (women with continued pregnancy). The genotypes of TAFI1040C/T locus and the sex hormone levels were compared among the pregnant women with different characteristics. The correlation between TAFI1040C/T locus genotype of the women in the study group and their pregnancy outcomes and sex hormone levels was analyzed. Results: In the study group, there were 41 women with inevitable abortion and 72 women with continued pregnancy. The levels of serum chorionic gonadotropin (β-hCG), estradiol (E2), and luteinizing hormone (LH) of the women in the study group were significantly lower than those of the women in the control group, and which of the women in group A were significantly lower than those of the women in group B (all P<0.05). The distributions of TAFI1040C/T gene of the women in the study group and the control group were in line with H-W balance. The frequency of TT gene of the women in the study group was significantly higher than that of the women in the control group, the frequency of CC gene of the women in the study group was significantly lower than that of the women in the control group, and there was significant difference in the distribution of TAFI1040C/T gene of the women between the two groups (P<0.05). In the study group, the frequency of TT gene of the women with inevitable abortion was significantly higher than that of the women with continued pregnancy, and the frequencies of CC and CT genes of the women with inevitable abortion were significantly lower than those of the women with continued pregnancy. The levels of β-HCG, P, and E2 of the women with CC, CT and TT genotypes had decreased gradually (all P<0.05). Conclusion: TAFI1040C/T allele T may be a risk gene of the threatened abortion and the adverse pregnancy outcomes of the women, and which may affect the pregnancy outcomes of the women by regulating their serumβ-HCG, P, and E2 levels.
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