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Abstract To analyze the correlation between the expression of CXCR5+CD4+T cells of infertility patients with endometriosis (EMS) and their pathogenesis and autoantibodies. Methods: 78 patients with EMS and infertility were selected in observation group, and 50 patients with EMS only were selected in control group from January 2019 to February 2021. The levels of endometrial antibody (EMAb), anti-ovarian antibody (AoAb), anti-sperm antibody (AsAb), thyroid autoantibody (ATA), anti-human chorionic gonadotropin antibody (AhCGAb), anti-β-2 glycoprotein 1 (α-β-2GP1), and CXCR5+CD4+T cell of the patients in the two groups were detected, and the correlation of which was analyzed. Results: The levels of AsAb (3.32±0.54), AoAb (2.94±0.28), EMAb (3.21±0.62), AhCGAb (3.64±0.59), α-β-2GP1 (3.28±0.61), and ATA (2.81±0.23) of the patients in the observation group were significantly higher than those (1.43±0.39, 2.13±0.34, 1.32±0.43, 2.03±0.48, 1.29±0.57, and 2.01±0.21) of the patients in the control group, and the CXCR5+CD4+T cell level (23.19±5.91%) of the patients in the observation group was significantly higher than that (9.34±2.88 %) of the patients in the control group (all P<0.05). The level of CXCR5+CD4+T cells of the patients with EMS was positively correlated with their incidence of infertility. The levels of AoAb, AsAb, EMAb, ATA, α-β-2GP1, and AhCGAb of the patients in the observation group were positively correlated with their CXCR5+CD4+T cells level (all P<0.05). Conclusion: The CXCR5+CD4+T cells level and the related antibody level of the patients with EMS and infertility all increase abnormally, and there is a positive correlation between the expression of CXCR5+CD4+T cells level of the infertility patients with EMS and their autoantibody level.
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