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| Comparison of clinical efficacy and postoperative prognosis within 1 year after operation of loop electrosurgical excision procedure and cervical cold knife conization for treating high-grade squamous intraepithelial lesion of the cervix |
| The 901th Hospital of the Joint Logistic Support Force of People's Liberation Army, Hefei, Anhui Province, 230031 |
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Abstract To compare the clinical efficacy and postoperative prognosis within 1 year after operation of loop electrosurgical excision procedure(LEEP) and cervical cold knife conization(CKC) for treating high-grade squamous intraepithelial lesion(HSIL) of the cervix. Methods: A total of 80 patients with HSIL were selected and were divided into group A(40 women given LEEP treatment) and group B(40 women given CKC treatment) according to the different treatment methods from January 2017 to December 2019. The perioperative indicators, complications, and short-term prognosis of the patients were compared between the two groups. Results: The operation time(7.87±2.14min) and the intraoperative blood loss(8.34±1.85ml) of the patients in group A were significantly lower than those(31.85±5.77min and 26.57±4.37ml) of the patients in group B(P<0.05). There were no significant differences in the postoperative complications rate(7.5% vs.12.5%) and the postoperative margin positive rate(7.50% vs.2.5%) of the patients between the two groups(all P>0.05). 12 months after operation, the positive rate of TCT/HPV screening(32.5%) and residual rate of lesions(25.0%) of the patients in group A were significantly higher than those(10.0% and 5.0%) of the patients in group B(P<0.05). There was no significant difference in the recurrence rate(7.5% vs. 5.0%) of the patients at 12 months after operation between the two groups(P>0.05). Conclusion: Compared with those of CKC, LEEP has the advantages of shorter operation time and less intraoperative bleeding, but the short-term prognosis after operation of the patients after CKC treatment is better than that of the patients after LEEP treatment. In clinic, the surgical method can be reasonably selected according to the needs of patients' conditions, so as to improve the treating effect of HSIL and its prognosis.
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