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| Influence of group B streptococcus infection in reproductive tract of pregnant women during the third trimester of pregnancy on their premature rupture of membranes, neonatal infection, and perinatal outcomes |
| Jiaozhou Central Hospital of Qingdao, Qingdao, Shandong Province, 266300 |
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Abstract To analyze the influence of group B streptococcus (GBS) infection in reproductive tract of pregnant women during the third trimester of pregnancy on their complications of premature rupture of membranes, neonatal infection, and perinatal outcomes. Methods: A total of 824 pregnant women with single fetus during the third trimester of pregnancy were selected as the research subjects, which included 400 women with premature rupture of membranes in research group and 424 women without premature rupture of membranes in control group from January 2019 to June 2020. The reproductive tract secretions of the women during 35-40 gestational weeks in the two groups were collected to detect the GBS, and the nasopharyngeal swabs of the newborns in the two groups were collected to detect the GBS. The correlation between the GBS infection complicating with premature rupture of membranes of the women and their neonatal GBS infection and adverse pregnancy outcomes was observed. Results: The infection rate of GBS (31.5%) of the women in the research group was significantly higher than that (10.4%) of the women in the control group. The rate of neonatal GBS infection (19.0%) in the research group was significantly higher than that (5.2%) in the control group (all P<0.05). Among 126 pregnant women with GBS infection in the research group, 87 cases had premature rupture time ≤24h, and 39 cases had premature rupture time >24h, and the neonatal GBS infection rate had significantly different between the women with different premature rupture time (51.7% and 79.5%). There were 92 cases with labor duration ≤24h and 34 cases with labor duration >24h, and the neonatal GBS infection rate of which (50.0% and 88.2%) had significant difference (all P<0.05). The incidences of intrauterine infection, puerperal infection, fetal distress, premature delivery, and amniotic fluid contamination of the women, and the neonatal asphyxia, pneumonia, and low weight in the research group were significantly higher than those of the women in the control group (all P<0.05), but there were no significant differences in the incidences of neonatal septicemia and jaundice between the two groups (P>0.05). Conclusion: GBS infection in reproductive tract of the pregnant women during the third trimester of pregnancy is closely related to their premature rupture of membranes, which will increase the risk of neonatal infection and adverse pregnancy outcomes, so which should be paid attention to in clinic, and early intervention and treatment should be given the pregnant women with GBS infection in reproductive tract.
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