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| Influence of intrauterine infection of group B streptococcus of pregnant women during the third trimester of pregnancy on their serum inflammatory factors levels and their pregnancy outcomes |
| Qingdao Central Hospital, Qingdao, Shandong Province, 266000 |
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Abstract To analyze the changes of serum inflammatory factors levels of pregnant women with intrauterine infection of group B streptococcus（GBS) during the third trimester of pregnancy, and to study the influence of the GBS infection on the pregnancy outcomes of the women. Methods: A total of 80 pregnancy pregnant women with intrauterine GBS infection from April 2018 to November 2019 were selected in observation group retrospectively, and 80 healthy pregnant women who received regular antenatal examination during the same period were selected in control group. The levels of serum hypersensitivity C-reactive protein (hS-CRP), tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6), and procalcitonin (PCT) of the women in the two groups were detected. The pregnancy outcomes of the women in the two groups were followed up. The different levels of serum inflammatory factors were compared among the women with different pregnancy outcomes. The influence of the serum inflammatory factors of the women on their adverse pregnancy outcomes were analyzed. Results: The levels of serum hS-CRP (9.16±2.67 mg/L), TNF-α (72.67±16.65 ng/L), IL-6 (122.59±20.16 ng/L), and PCT (80.61±16.77 pg/ml) of the women in the observation group were significantly higher than those of the women in the control group, and which of the pregnant women with adverse pregnancy outcomes were significantly higher than those of the women with normal pregnancy outcomes. The incidences of the premature delivery (15.0%), the premature rupture of membranes (16.3%), the amniotic fluid contamination (30.0%), the puerperal infection (18.8%), the fetal distress (23.8%), and the neonatal asphyxia (17.5%) of the women in the observation group were significantly higher than those of the women in the control group (all P<0.05). There were no significant differences in the incidences of physiological jaundice and neonatal infection of the women between the two groups (P>0.05). Logistic multifactor regression analysis showed that the abnormal increase of HS-CRP, TNF-α, IL-6, and PCT levels of the women with intrauterine GBS infection during the third trimester of pregnancy were the risk factors of their adverse pregnancy outcomes (P<0.05). Conclusion: The levels of the serum inflammatory factors, such as hs-CRP, TNF-α, IL-6, PCT, of the pregnant women with intrauterine infection of GBS during the third trimester of pregnancy are abnormal increase, and which are all related to their adverse pregnancy outcomes.
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