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| Effect of ethinyl estradiol and cyproterone combined with pioglitazone for treating infertility women with polycystic ovarian syndrome and type 2 of diabetes mellitus |
| Panzhihua Hospital of Integrated Traditional Chinese Medicine and Western Medicine (Affiliated Hospital of Panzhihua College), Sichuan Province, 617000 |
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Abstract To analyze the effect and safety of ethinyl estradiol and cyproterone combined with pioglitazone for treating infertility women with polycystic ovarian syndrome (PCOS) and type 2 of diabetes mellitus (T2DM).Methods: 122 infertility women with PCOS and T2DM were selected and were divided into control group and research group (61 cases in each group) according to the simple random number table method from January 2017 to December 2019.The women in the control group were given ethinylestradiol and cyproterone, and the women in the research group were given ethinylestradiol and cyproterone combined with pioglitazone.The changes of the levels of sex hormones and oxidative stress indicators of the women before and after treatment, and the rates of pregnancy, ovulation, and adverse reactions of the women after treatment were compared between the two groups.Results: After treatment, the levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), and androstenadione (A2) of the women in the two groups had decreased significantly, but the sex hormone binding globulin (SHBG) level had increased significantly, and the change range of the women in the research group was significantly more than that of the women in the control group.After treatment, the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of the women in the two groups had increased significantly, but the levels of malondialdehyde (MDA) and late oxide protein product (AOPP) of the women in the two groups had decreased significantly, and the change range of the women in the research group was significantly more than that of the women in the control group (all P＜0.05).The pregnancy rate (36.1%) and the ovulation rate (85.3%) of the women in the research group were significantly higher than those (18.0% and 63.9%) of the women in the control group, and the total incidence of adverse reactions (8.2%) of the women in the research group was significantly lower than that (21.3%) of the women in the control group (all P＜0.05).Conclusion: Ethinyl estradiol and cyproterone combined with pioglitazone for treating infertility women with PCOS and T2DM can effectively improve their levels of sex hormones, reduce their oxidative stress response, and increase their ovulation rate with higher safety.
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