To explore the effects of Nuangong yunzi capsules combined with progesterone for treating infertility patients induced by luteal phase deficiency (LPD) on their endometrial thickness, inflammatory factors, and pregnancy outcomes.Methods: A total of 120 infertility patients induced by LPD were enrolled and divided into control group (58 cases) and observation group (62 cases) according to randomized control principle from June 2018 to June 2019.The patients in the control group were treated with progesterone, while the patients in the observation group were treated with Nuangong yunzi capsules combined with progesterone.The endometrial thickness, the levels of sex hormones and inflammatory factors, the clinical efficacy, and the pregnancy outcomes of the patients before and after treatment were compared between the two groups.Results: The levels of progesterone and estradiol, and the endometrial thickness of the patients in the two groups after treatment were significantly higher than those before treatment, but the levels of interleukin-2 and tumor necrosis factor -α of the patients in the two groups after treatment were significantly lower, and the improvement degree of which of the patients in the observation group was significantly better than that of the patients in the control group (all P＜0.05).The total clinical effective rate (90.3%) of the patients in the observation group was significantly higher than that (70.7%) of the patients in the control group, the ovulation rate (90.3%) and the pregnancy success rate (59.7%) of the patients in the observation group were significantly higher than those (58.6% and 32.8%) of the patients in the control group (all P＜0.05).Conclusion: Nuangong yunzi capsules combined with progesterone for treating infertility patients induced by luteal phase deficiency can effectively regulate theire levels of sex hormones and their endometrial receptivity, can reduce their levels of inflammatory factors, and can increase their pregnancy rate.