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Abstract To explore the efficacy of self-made Bushen huayu recipe combined with gestrinone for treating women with endometriosis (EMs) of renal deficiency and blood stasis type, and to study its mechanism of action. Methods: 88 women with EMs of renal deficiency and blood stasis type were selected as the observation objects, and were divided into two groups by convenience sampling method. 44 women in the control group were treated with gestrinone for 3 months, and 44 women in the observation group were treated with self-made Bushen huayu recipe combined with gestrinone for 3 months. The quantitative scores of TCM symptoms before and after treatment, such as abdominal pain during menstruation, lumbosacral pain, oligomenorrhea, dizziness, insomnia, and hypaphrodisia, the levels of the estradiol (E2), follicle stimulating hormone (FSH), and luteinizing hormone (LH), the levels of serum cancer antigen 125 (CA125), prostaglandin E2 (PGE2), prostaglandin F2α (PGF2α), vascular endothelial growth factor (VEGF), and matrix metalloproteinase-9 (MMP-9), the values of high and low shear viscosity of whole blood, plasma viscosity, and hematocrit, and the dysmenorrhea score of the women in the two groups were observed and analyzed. The clinical efficacy and safety of the treatment of the women in the two groups were evaluated. The recurrence rate was counted after 6 months of followed up. Results: After treatment, the scores of TCM symptoms of the women in both groups had decreased significantly, and which of the women in the observation group were significantly lower than those of the women in the control group. The levels of E2, LH, FSH, PGE2 and PGF2αof the women in both groups had decreased significantly after treatment, and which of the women in the observation group were significantly lower than those of the women in the control group. After treatment, the levels of VEFG and MMP-9 of the women in the observation group had no significantly change, but which of the women in the control group had decreased significantly. The values of high and low shear viscosity of whole blood, plasma viscosity, and hematocrit, and the visual analogue scale of pain of the women in both groups had decreased significantly after treatment, and which of the women in the observation group were significantly lower than those of the women in the control group (all P<0.05). The total effective rate (93.2%) of the women in the observation group was significantly higher than that (81.8%) of the women in the control group (P<0.05), and there was no significant difference in the adverse reaction rate (15.9% vs. 20.5%) of the women between the two groups (P>0.05). The recurrence rate (2.3%) of the women in the observation group was significantly lower than that (11.4%) of the women in the control group (P<0.05). Conclusion: Self-made self-made Bushen huayu recipe combined with gestrinone for treating women with endometriosis of renal deficiency and blood stasis type can alleviate the symptoms of EMs and has significant clinical efficacy, which mechanism may be related to the regulation of sex hormone levels, serum biochemical indicators, and hemorheology of these women.
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