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| Comparative study of the effect of nasal intermittent positive pressure ventilation and synchronized intermittent mandatory ventilation for treating neonatal respiratory distress syndrome of premature infants |
| Western Theater General Hospital, Chengdu, Sichuan Province, 610083 |
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Abstract To explore the comparative effect of nasal intermittent positive pressure ventilation (NIPPV) and synchronized intermittent mandatory ventilation (SIMV) for treating the premature infants with neonatal respiratory distress syndrome (NRDS). Methods: 102 premature infants with NRDS were selected and were divided into group A (51 infants with NIPPV) and group B (51 infants with SIMV) by random number table method from June 2021 to June 2023. The clinical efficacy after 3 days of treatment, the clinical related indicators values, the values of blood gas indicators, such as partial pressure of carbon dioxide (PaCO2), partial pressure of oxygen (PaO2) and arterial oxygen saturation (SaO2), the levels of inflammatory indicators, such as interleukin-6 (IL-6), high mobility group protein-1 (HMGB-1), tumor necrosis factor-α (TNF-α), and bone morphogenetic protein-7 (BMP-7), and the values of respiratory mechanics indicators, such as tidal volume (VT), dynamic lung compliance (CD) and oxygenation index (OI), of the infants before and after treatment were compared between the two groups. The incidence of the adverse reactions of the infants in the two groups during treatment was recorded. Results: The clinical efficacy (88.2%) of the infants in group A after 3d of treatment was significantly higher than that (70.6%) of the infants in group B. The breathing machine use time, the oxygen cure time, the time of hospital stay, the apnea number of the infants in group A were significantly lower than those of the infants in group B. The PaCO2 value and the levels of IL-6, HMGB-1, TNF-αand BMP-7 of the infants in the two groups had decreased significantly, and which of the infants in group A were significantly lower than those of the infants in group B. The PaO2 and SaO2 values, and the VT, CD and OI levels of the infants in the two groups had increased significantly, and which of the infants in group A were significantly higher than those of the infants in group B. The incidence of adverse reactions (11.8%) of the infants in group A was significantly lower than that (29.4%) of the infants in group B (all P<0.05). Conclusion: NIPPV for treating premature infants with NRDS has better efficacy and can significantly improve the blood gas indicators, enhance the respiratory function, inhibit the inflammatory response and reduce the risk of complications of the infants.
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