To investigate the correlation between the values of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and immature reticulocyte index (IRI) of the women with recurrent spontaneous abortion (RSA) and their pregnancy outcomes, and to study their predictive values for RSA. Methods: This study was a prospective study.150 women with RSA were selected in observation group, and 150 healthy women of childbearing age were selected in control group from January 2019 to January 2021. The values of blood MCV, MCH, and IRI of the women in the two groups were measured. The value of the values of blood MCV, MCH, and IRI of the women with RSA for predicting their pregnancy outcomes was analyzed. Results: The values of IRI (2.89±2.37%), and MCH (27.06±2.37 pg) of the women in the observation group were significantly lower than those (5.39±2.69% and 29.98±2.39 pg) of the women in the control group, and the MCV value (92.43±2.22 fL) of the women in the observation group was significantly higher than that (88.40±2.37 fL) of the women in the control group. In the observation group, the values of IRI and MCH of the women with adverse pregnancy outcomes were significantly lower than those of the women with normal pregnancy outcomes, but the MCV value of the women with adverse pregnancy outcomes was significantly higher (all P<0.05). The values of IRI and MCH of the women in the observation group were negatively correlated with their adverse pregnancy outcomes, but were positively correlated with their MCV value (all P<0.05). The combined detections of IRI, MCV, and MCH had predictive value for predicting the adverse pregnancy outcomes of the women with RSA, which had higher diagnostic specificity. The critical values of the IRF value, the MCV value, and the MCH value for predicting RSA were 2.11%, 93.33fL, and 26.66pg, respectively. Conclusion: The values of MCV, MCH, and IRI of the women with RSA are correlated with their adverse pregnancy outcomes. The values of the combined detections of MCV, MCH, and IRI of the women for predicting their RSA has certain clinical value.