To explore the clinical efficacy of acupuncture combined with pulsed intravenous infusion of oxytocin for treating pregnant women with primary uterine inertia. Methods: A total of 120 pregnant women with primary uterine inertia were selected and were randomly divided into control group and study group from May 2018 to May 2020. The women in the control group were given pulse intravenous infusion of oxytocin for treating primary uterine inertia asthenia, and the women in the study group were given acupuncture combined with pulsed intravenous infusion of oxytocin for treating primary uterine inertia asthenia. The clinical efficacy of the women was compared between the two groups. Results: The total effective rate(81.7%) of the women in the study group was significantly higher than that(65.0%) of the women in the control group, the rate of nature delivery(53.3%) of the women in the study group was significantly higher than that(38.3%) of the women in the control group, and the rate of cesarean section(23.3%) of the women in the study group was significantly lower than that(33.3%) of the women in the control group. The duration of the first stage of labor(418.46±115.37min) and the duration of total stage of labor(479.46±148.34min) of the women in the study group were significantly lower than those of the women in the control group(P<0.05). The incidence of adverse delivery outcomes(6.7%), mainly included fetal distress, postpartum hemorrhage, neonatal asphyxia and neonatal infection, of the women in the study group was significantly lower than that(21.7%) of the women in the control group(P<0.05). Conclusion: Acupuncture combined with pulsed intravenous infusion of oxytocin for treating pregnant women with primary uterine inertia can effectively improve the uterine contraction capacity and the opening speed of cervix uteri. It is of great clinical significance for accelerating the labor process and improving the delivery mode, and can reduce the occurrence of postpartum complications.