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| Drug resistance of the group B streptococcus infection of pregnant women during the third trimester of pregnancy and its influence on the coagulation function of the women |
| 1.Linhai Maternal and Child Health Care Hospital, Zhejiang Province, 317000；2.Taizhou Hospital, Zhejiang Province |
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Abstract To investigate the drug resistance of the group B streptococcus (GBS) infection of women during the third trimester of pregnancy, and to study its influence on the coagulation function. Method: The clinical data of 286 pregnant women during the third trimester of pregnancy from February 2017 to February 2020 were analyzed retrospectively. According to the situation of GBS infection (confirmed by bacterial culture), these women were divided into group A (96 women with GBS infection) and group B (190 women without GBS infection). The coagulation function and pregnancy outcomes of women in the two groups were evaluated. The women in group A were given antibiotics, and the coagulation function of the women and neonatal outcomes were observed after treatment. Results: 121 strains of GBS had showed no resistance to vancomycin, ampicillin, penicillin G, cefepime, ceftriaxone, meropenem and linezolid. Antibacterial strains resistant to erythromycin, levofloxacin, tetracycline, gatifloxacin and clindamycin had been detected. The values of prothrombin time (PT), activated partial thromboplastin time (APTT), international normal ratio (INR), and thrombin time (TT) of the women in group A were significant lower than those of the women in group B, while the fibrinogen (FIB) value, and the rates of premature rupture of membranes, intrauterine infection, fetal distress, and premature delivery of the women in group A were significant higher than those of the women in group B (P＜0.05). In group A, the values of PT, APTT, INR and TT of the women had increased
significantly after treatment for 3 days and 7 days, while the FIB value of the women had decreased significantly after treatment (P＜0.05). In group A, the values of PT, APTT and INR of the women after continuous treatment for 7 days were significant higher than those of the women after continuous treatment for 3 days, while the FIB value of the women after continuous treatment for 7 days was significant lower than those of the women after continuous treatment for 3 days (P＜0.05). In group A, the women had been treated with penicillin sodium, there were 1 (2.1%) case with neonatal pneumonia, 1 (2.1%) case with neonatal asphyxia, 2 (4.2%) cases with neonatal pathological jaundice, and 1 (2.1%) case with neonatal meningitis, and which total incidence of neonatal complications was 8.3%. Conclusion: GBS infection of the pregnant women is the important cause affecting their coagulation function and pregnancy outcomes. Appropriate antibiotic treatment is the key to improving pregnancy outcomes and reducing neonatal complications.
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