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| Correlation between arterial elasticity of pregnant women with preeclampsia and their oxidative stress injury and vascular endothelial function |
| Zhoukou Maternal and Child Health Care Hospital (Zhoukou Children's Hospital), Henan Province, 466000 |
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Abstract To investigate the correlation between brachial ankle artery pulse velocity (baPWV) of pregnant women with preeclampsia (PE) and their oxidative stress injury and vascular endothelial function. Methods: 213 women with PE were selected as study subjects from April 2016 to May 2020. According to the quaternion spacing of baPWV value, these women were divided to Q1 group (53 cases), Q2 group (54 cases), Q3 group (53 cases), and Q4 group (53 cases). The indexes of serum oxidative stress injury and vascular endothelial function injury of the women were compared among these groups, and the correlation between baPWV value and the indexes of serum oxidative stress injury and vascular endothelial function injury was analyzed. Results: The serum levels of MDA, AOPPs and LHP of the women in group Q4 were significant higher than those of the women in group Q3, and which were also significant higher than those of the women in group Q1 and group Q2 (P＜0.05), but the serum levels of MDA, AOPPs and LHP of the women in group Q1 had no significant different from those of the women in group Q2 (P＞0.05). The serum T-AOC level of the women in group Q1, group Q2, group Q3, and group Q4 had gradually decreased (P＜0.05). The levels of serum sEng, sFlt-1 and ET-1 of the women in group Q4 were significant higher than those of the women in group Q3, and were also significant higher than those of the women in group Q1 and group Q2 (P＜0.05), but which of the women in group Q1 had no significant different from those of the women in group Q2 (P＞0.05). The serum VEGF level of the women in group Q1, group Q2, group Q3, and group Q4 had gradually decreased (P＜0.05). The baPWV value was positively correlated with the levels of serum sEng, sFlt-1, MDA, and LHP (P＜0.05), but which was negatively correlated with serum VEGF and TAOC levels (P＜0.001), and had no correlation with serum ET-1 and AOPPs levels (P＞0.05). Conclusion: The artery elasticity of pregnant women with PE is worse, the more serious of oxidative stress injury and vascular endothelial function injury.
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