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| Evaluation of the effect of endometrial micro stimulation combined with drug therapy for improving pregnancy outcomes of patients with AID biochemical pregnancy |
| National Research Institute for Family Planning, Beijing,100081 |
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Abstract To explore the influence of endometrial micro stimulation combined with drug therapy for improving pregnancy outcomes of patients with more than one time of biochemical pregnancy after artificial insemination with donor sperm (AID) on their endometrial morphology and pregnancy outcomes. Methods: A total of 78 patients who had two or more biochemical pregnancies after receiving AID treatment in our center were enrolled from January 2016 to December 2019. The patients were randomly divided into intervention group (n=40) and control group (n=38). The patients in the intervention group underwent endometrial scratching in mid-luteal phase before AID cycle, but which was not performed in the control group. AID operation was performed for the patients in the two groups before and after ovulation. After that, the patients in the intervention group were given drugs to improve their endometrial receptivity in the AID cycle, while the patients in the control group were not intervened. Results: 5 cases in 78 patients had withdrawn from the study, and 38 patients in intervention group and 35 patients in control group were included in the study in the end. There were no significant differences in the indicators of endometrial ultrasound monitoring before AID treatment between the two groups (P>0.05). The endometrial thickness during treatment, the ratio of types A endometrium on the day of HCG trigger, and the endometrial thickness on the day of the window period of the patients in the intervention group were 9.88±0.96 mm, 84.2%, and 10.18±0.98 mm, respectively, which were significant higher than those (8.93±0.49 mm, 62.9%, and 9.43±0.44 mm) of the patients in the control group (P<0.05). After treatment, the increased amplitude of endometrial thickness, the ratio of types A endometrium on the day of HCG and the increased amplitude of endometrial thickness on the day of window period of the patients in the intervention group were 1.27±0.77, 26.3%, and 0.85±0.52, respectively, which were significant higher than those (0.33±0.32, 5.7%, and 0.23±0.20) of the patients in the control group (P<0.05). The clinical pregnancy rate during treatment (36.8%) of the patients in the intervention group was significant higher that (14.3%) of the patients in the control group (P<0.05). There were no significant differences in the biochemical pregnancy rate (0% vs. 5.71%) and the miscarriage rate (0% vs. 20%) between the two groups (P>0.05). Conclusion: The endometrial micro stimulation combined with drug therapy can improve the endometrial status and pregnancy outcomes of patients with AID biochemical pregnancy.
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