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| Efficacy of Gongliuxiao capsule for adjuvant treating women with dysmenorrhea because of endometriosis and its influence on their serum levels of PGE2, PGF2α, NGF, and OT |
| Baoshan District Integrated Traditional Chinese and Western Medicine Hospital, Shanghai, 201900 |
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Abstract To explore the efficacy of Gongliuxiao Capsules for adjuvant treating women with dysmenorrhea because of endometriosis (EMS), and to study its influence on serum levels of prostaglandin E2 (PGE2), prostaglandin F2α (PGF2α), nerve growth factor (NGF), and oxytocin (OT) of the women. Methods: 127 women with dysmenorrhea because of EMS were randomly divided into control group (n=62) and observation group (n=65). The women in the control group were treated with gestrinone and mifepristone for 3 months, and the women in the observation group were treated with supplemented with Gongliuxiao capsule treatment combined with gestrinone and mifepristone for 3 months. The efficacy of the women was compared between the two groups. The scores of the Chinese version of COX dysmenorrhea symptom scale (CMSS) and pain visual analog scale (VAS) of the women in the two groups were evaluated, the uterine volume, endometrial thickness and mass diameter of the women in the two groups after treatment was measured, and the serum levels of PGE2, PGF2α, NGF, OT, cancer antigen 125(CA125), vascular endothelial growth factor(VEGF), and transforming growth factor β1(TGF-β1) of the women in the two groups were detected. Results: After treatment, the total effective rate of the women in the observation group (96.9%) was significant higher than that (83.9%) of the women in the control group, and the CMSS score, VAS score, uterine volume, endometrial thickness, mass diameter, the serum levels of PGE2, PGF2α, NGF, OT, CA125, VEGF, and TGF-β1 of the women in the observation group were significant lower than those before treatment and than those of the women in the control group(P<0.05). Conclusion: Gongliuxiao capsule for adjuvant treating women with dysmenorrhea because of EMS has definite effect, which can relieve dysmenorrhea and accompanying symptoms. The mechanism may be related to the down-regulation of PGE2, PGF2α, NGF and OT levels of the women.
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