To explore the effect and mechanism of vascular endothelial growth factorA (VEGF-A) inhibitor intervening model rats with endometriosis. Methods: 35 SD healthy female rats were selected and divided in 2 groups, which included 5 rats in the normal group and 30 rats were in the endometriosis model group. And the 30 rats in the endometriosis model group were randomly divided into group A (10 rats were given saline), group B (10 rats were given danazol), and group C (10 rats were given VEGF-A inhibitor). The levels of estradiol (E2), progesterone (P), follicle stimulating hormone (FSH), luteinizing hormone (LH), C-reactive protein (CRP), interleukin-8 (IL-8), interleukin-6 (IL-6) of rates in the four groups were detected, and the levels of Hypoxia inducible factor-1α (HIF-1α) and VEGF, and the expression of Bcl-2, Bax, caspase-3 proteins of rates in the four groups were detected by Western blot. Results: The levels of E2, P, FSH, LH, CRP, IL-8 and IL-6, and the relative expression of VEGF, HIF-1α, Bcl-2 and Caspase-3 of rats in group C were significant lower than those in group A and B, but the relative expression level of Bax of rats in group C was significant higher (P<0.05). Conclusion: VEGF-A inhibitors used for intervening the model rats with endometriosis can regulate their sex hormones level, inhibit the inflammation and growth of heterotopic endometrium tissue, and promote apoptosis of ectopic endometrium tissue.