To compare the effectiveness and safety of MCu375 intrauterine device (IUD) and TCu380A IUD used in China. Methods：Electronic search was used to identify the literatures about the clinical effect and safety of MCu375 IUD and TCu380A IUD in different database from the construction of the database until December 2018, which included the randomized controlled trials (RCT) and quasi-RCT. The literatures were screened, evaluated, and synthesis analyzed by Endnote x7 and RevMan5.3.3 software. Results: Thirteen studies were included in this Meta analysis. The cumulative pregnancy rates of MCu375 IUD in 6 months, 12 months and 24 months after inserted were significant higher than those of TCu380A IUD, which’s RR (95%CI) were 6.96 (1.59-30.50)，1.95 (1.51-2.53), and 1.90(1.16-3.13). The expulsion rates of MCu375 IUD in 6 months and 12 months after inserted were significant different from those of TCu380A IU, which’s RR (95%CI) were 2.40 (1.29-4.47) and 2.51 (2.09-3.01). The cumulative medical removal rates of MCu375 IUD in 6 months, 12 months and 24 months after inserted had no significant different from those of TCu380A IUD. Conclusion: The rate of pregnancy of MCu375 IUD used is higher than that of TCu380A IUD used in China.

Effect of different treatments of cervical lesions of pregnant women on their pregnancy outcomes and delivery mode[J]. 中国计划生育学杂志, 2020, 28(7): 1108-1113.