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| The levels of serum miR-494-5p and miR-1304-3p of patients with endometriosis and its relationship to infertility |
| 133rd Central Hospital of The People's Liberation Army, Zhengzhou, Henan Province, 450007 |
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Abstract To investigate the levels of serum miR-494-5p and miR-1304-3p of patients with endometriosis, and to analyze their relationship to infertility.Methods: A total of 52 patients with endometriosis were selected in experimental group from May 2016 to August 2017, and 52 healthy women were selected in control group during the same period. The levels of serum miR-494-5p and miR-1304-3p of women in the two groups were detected by fluorescence quantitative method, and visual analog scale (VAS) was used to evaluate the dysmenorrhea degree. Results: The levels of serum miR-494-5p and miR-1304-3p of women in experimental group were significant higher than those of women in control group (P<0.05). In experimental group, the serum miR-494-5p and miR-1304-3p levels of women with stage IV endometriosis were significant higher than those women with I-III endometriosis (P<0.05), and the levels of miR-494-5p and miR-1304-3p of women with heavy dysmenorrhea were significantly higher than those of women with moderate, mild, or no dysmenorrhea (P<0.05), and the levels of miR-494-5p and miR-1304-3p of women with infertility were significant higher than those of women without infertility (P<0.05). Conclusion: The serum levels of miR-494-5p and miR-1304-3p of patients with endometriosis gradually increase with the progression of the disease, and which are expression higher in the women with infertility. So the serum levels of miR-494-5p and miR-1304-3p maybe have great clinical significance for evaluating the progression of the disease of patients with membranous, and it is worthy of further study.
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