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| A study of TORCH infection of women before pregnancy and its relevant to adverse pregnancy outcomes |
| 1. Maternal and Child Health and Family Planning Service Center of Lingqiu County, Shanxi Province, 034400; 2. The Second People's Hospital of Shanxi Medical University |
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Abstract To investigate the TORCH infection of women before pregnancy, and to analyze the correlation of TORCH infection and the rate of stillbirth or spontaneous abortion of women after pregnancy. Methods: Peripheral blood samples from 1705 women who experienced the pre-pregnant examination were collected from January 2015 to January 2017. The infection situations of toxoplasma gondii (TOX), rubella (RV) and cytomegalovirus (CMV) were detected by enzyme-linked immunosorbent assay. The pregnant women were followed-up, and the relationship between the rate of TOX, RV, CMV infection of women and their pregnancy outcomes were analyzed. Results: A total of 119 (7.0%) women with TORCH infections in the included 1705 women were diagnosed, and among them, there were 24 women with TOX infection (1.4%), 42 women with RV infection (2.5%), 53 women with CMV infection (3.1%). The infection rates of TOX, RV and CMV of women with 20-30 years old were significant higher than those of women with 31-39 years old (P<0.05). 1620(95.0%) women were followed-up and 1102(68.0%) women were pregnant. In these 1102 pregnant women, there were 38 women (3.45%) with stillborn, 43 women (3.9%) with spontaneous abortion, and 81 women (7.35%) with abnormal pregnancy. The rate of adverse pregnancy outcomes of women with TORCH infection was significant higher than that of women without TORCH infection (P<0.05). The rates of stillborn and stillborn, and spontaneous abortion of women with TOX IgG(﹢),TOX IgM(﹢),RV IgG(﹢),CMV IgG(﹢), or IgM(﹢) were significant higher than those of women with TOX IgG(-),IgM (-),RV IgG(-), CMV IgG(-), or IgM (-)(P<0.05). Women with TOX IgG(﹢),TOX IgM(﹢),RV IgG(﹢),CMV IgG(﹢), or IgM(﹢) were the independent risk factors of stillbirth and spontaneous abortion occurred. Conclusions: TORCH infection is closely related to stillbirth, stillbirth and other adverse pregnancy outcomes, and women with 20-30 years old have higher rate of TORCH infection, so pre-pregnancy TORCH screening should be strengthen.
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