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| Clinical value of human papillomavirus DNA detection combined with the levels of squamous cell carcinoma antigen, carbohydrate antigen 19-9 and alphafetoprotein for diagnosing cervical cancer |
| Hangzhou Obstetrics and Gynecology Hospital Hangzhou, Zhejiang Province, 310000 |
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Abstract To analyze the clinical value of human papillomavirus DNA(HPV-DNA) detection combined with the levels of squamous cell carcinoma antigen(SCC-Ag), carbohydrate antigen 19-9(CA19-9) and alpha-fetoprotein (AFP) for diagnosing cervical cancer. Methods: The clinical data of 80 women with cervical cancer(in group A) and 80 patients with benign cervical lesions(in group B) between March 2018 and March 2022 were collected respectively. 50 healthy women were enrolled in group C. The expression levels of the serum SCC-Ag, CA19-9 and AFP, and the positive rates of HPV-DNA, SCC-Ag, CA19-9 and AFP of the women were compared among the three groups. In group A, the expression levels of the serum SCC-Ag, CA19-9 and AFP, and the positive rates of HPVDNA, SCC-Ag, CA19-9 and AFP were compared among the women with different FIGO stages. The results of the pathological diagnosis was used as the “gold standard”, the efficiencies of the HPV-DNA level, the SCC-Ag level, the CA19-9 level or the AFP level alone, and the combination of the HPV-DNA and the SCC-Ag CA19-9 and AFP levels of the women for diagnosing their cervical cancer were evaluated. Results: The expression levels of the serum SCC-Ag, CA19-9 and AFP of the women in group A were significantly higher than those of the women in group B and those of the women in group C. The positive rates of HPV-DNA, SCC-Ag, CA19-9 and AFP of the women in group A were also significantly higher than those of the women in group B and those of the women group C. In group A, the expression levels of the serum SCC-Ag, CA19-9 and AFP of the women with stage III-IV cervical cancer were significantly higher than those of the women with stage I-II cervical cancer, and the positive rates of HPV-DNA, CA19-9 and AFP of the women with stage III-IV cervical cancer were also significantly higher than those of the women with stage I-II cervical cancer(all P<0.05). The sensitivity(96.3%) and the accuracy(91.8%) of the combination of the HPV-DNA and the SCC-Ag, CA19-9 and AFP levels of the women for diagnosing their cervical cancer were significantly higher than those of the HPV-DNA level, the SCC-Ag level, the CA19-9 level or the AFP level alone, and the specificity of the AFP level(100.0%) of the women for diagnosing their cervical cancer was the highest(P<0.05). Conclusion: The combination of the HPV-DNA and the SCC-Ag, CA19-9 and AFP levels of the women for diagnosing their cervical cancer can increase the efficacy.
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