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| Factors influencing the fetal protection outcomes of pregnant women with threatened abortion and their correlation with the levels of serum soluble human leukocyte antigen-G and anticardiolipin antibody |
| 1.Ziyang Hospital, West China Hospital of Sichuan University, Ziyang Central Hospital, Ziyang, Sichuan Province,641300; 2.Chengdu Jinxin Reproductive Medicine and Genetics Institute, Chengdu |
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Abstract To explore the factors influencing fetal protection outcomes of pregnant women with threatened abortion, and to analyze their correlation with the levels of serum soluble human leukocyte antigen-G(sHLA-G) and anticardiolipin antibody(ACA) of the women. Methods: The clinical data of 80 pregnant women with threatened abortion who admitted to the hospital from June 2021 to June 2023 were collected retrospectively. These women were divided into group A(women with the failed fetal protection) and group B(women with the successful fetal protection) according to the outcome of their fetal protection. The general information of the women was compared between the two groups. The levels of sHLA-G and ACA of the women in the two groups were detected by enzyme-linked immunosorbent assay. Single factor analysis and Pearson correlation analysis method were used to analyze the influencing factors of the fetal protection outcomes of the women with threatened abortion and the correlation between the fetal protection outcomes of the women with threatened abortion and their serum sHLA-G and ACA levels. Results: There were significant differences in the age, the history of abortion, the complicated with vaginitis, the gestational diabetes mellitus, and the situation of exposure to the toxic chemicals of the women between the two groups. The level of sHLA-G(7.43±1.20 U/ml) of the women in group A was significantly lower than that(50.14±4.56 U/ml) of the women in group B, and the positive rate(74.1%) of ACA of the women in group A was significantly higher than that(20.8%) of the women in group B(all P<0.05). Logistic regression analysis showed that the advanced age, the previous abortion history, the complicated with vaginitis, the gestational diabetes mellitus, the situation of exposure to the toxic chemicals, the low sHLA-G level and the high positive rate of ACA of the women with threatened abortion were the important factors affecting their fetal protection outcomes. Pearson correlation analysis showed that the age, the history of abortion, the complicated with vaginitis, the gestational diabetes mellitus, the situation of exposure to the toxic chemicals of the women with threatened abortion were negatively correlated with their serum sHLA-G level, and were positively correlated with their ACA positive rate(all P<0.05). Conclusion: The fetal protection outcomes of the pregnant women with threatened abortion may be related to their age, previous abortion history, complicated with vaginitis, gestational diabetes mellitus, exposure to the toxic chemicals, serum sHLA-G level and ACA positive rate, and the close attention should be paid to these factors in clinical practice. The changes of the sHLA-G level and the ACA positive rate of the pregnant women should be monitored to guide the early intervention in clinic to ensure the safety of the mothers and the infants.
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