To explore the analgesic effect of the quadratus lumborum block by the dexmedetomidine combined with ropivacaine during laparoscopic total hysterectomy(LTH) of patients, and to study its influence on the hemodynamics of the patients. Methods: 72 patients who wanted LTH under general anesthesia were selected and were randomly divided into group A(36 cases) and group B(36 cases) by envelope method from January 2021 to March 2023. The patients in group A were given quadratus lumborum block by dexmedetomidine combined with ropivacaine during operation, while the patients in group B were given quadratus lumborum block by ropivacaine. The postoperative recovery situation, such as the awakening time, the first exhaust time, the first analgesic pump used time, the opioid dosage, the analgesic effect evaluated by visual analogue scale(VAS) and Ramsay sedation scale scores, the values of hemodynamics, such as heart rate(HR), systolic blood pressure(SBP) and mean arterial pressure(MAP) of the patients at the time of entering the room(T0), tracheal intubation(T1), skin incision(T2), placement of endoscopy(T3), beginning of surgery(T4), end of surgery(T5) and extubation(T6), and postoperative adverse reactions of the patients were compared between the two groups. Results: The postoperative recovery time(9.5±0.9 min) and the first exhaust time(12.9±1.7 min) of the patients in group A were significantly shorter than those(12.9±1.7 min and 16.0±2.1 min) of the patients in group B. The first time of the analgesic pump used(11.87±1.06h) of the patients in group A was significantly later than that(8.36±0.98h) of the patients in group B. The dosage of sufentanil(121.83±7.71μg) of the patients in group A in 48 h after operation was significantly less than that(138.79±8.12μg) of the patients in group B, and the VAS score(2.87±0.64 points) of the patients in group A in 12 h after operation was significantly lower than that(3.86±0.78 points) of the patients in group B. The Ramsay sedation score(2.99±0.52 points) of the patients in group A was significantly higher than that(2.53±0.46 points) of the patients in group B. the values of HR, MAP and SBP of the patients in group A at T1-T6 were significantly lower than those of the patients in group B. The incidence(8.3%) of the adverse reactions, such as dizziness and nausea, of the patients in group A was significantly lower than that(25.0%) of the patients in group B(all P<0.05). Conclusion: The quadratus lumborum block by dexmedetomidine combined with ropivacaine during LTH of the patients can effectively reduce their opioid dosage, relieve their postoperative analgesia, maintain their hemodynamic stability and reduce their incidence of adverse reactions.