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| Discussion of the disposal mode of only 1 or 2 embryos with extremely poor morphological score in cleavage stage of women with a single in-vitro fertilization cycle. |
| Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital), NHC Key Laboratory of Male Reproduction and Genetics, Guangzhou, Guangdong Province, 510600 |
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Abstract To compare the clinical outcomes of the fresh embryo transfer or blastocyst culture by only 1 or 2 embryos with 4 or 5 cells and III grade low morphological score in cleavage stage of women with a single in-vitro fertilization(IVF) cycle. Methods: 185 cycles of single in vitro fertilization-embryo transfer(IVF-ET) by 1 or 2 III grade embryos with 4 or 5 cells in cleavage stage of the women from Jan, 2013 to Dec, 2022 were collected in this study. According to the intention of the embryos transfer, these women were divided into group A(72 women with fresh embryos transfer) and group B(113 women with blastocyst culture). The incidences of the effective embryo utilization, the accumulating clinical pregnancy rate in the cycles of eggs obtained and the accumulating live birth of the women in the two groups were observed. Results: In group B, the available blastocyst formation rate of the women was 3.9%, 8 available blastocysts were formed by the blastocyst culture from 208 embryos with low morphological score, and the clinical pregnancy rate and the live birth rate of the women after blastocyst transfer were 75% and 50%. In group A, the pregnancy rate of the women was 19.4%. The rate of effective embryo utilization(12.5%) of the women in group A was significantly higher than that(2.9%) of the women in group B. The cumulative pregnancy rate(19.4%) and the cumulative live birth rate(11.1%) of the women in group A were significantly higher than those(5.3% and 2.7%) of the women in group B(all P<0.05). Conclusion: The blastocyst formation rate of the embryo with 4/5 cells and low poor morphological score is low, while the pregnancy rate of the formed blastocyst is high. If the woman has no other
embryo transfer option and has a strong desire to the embryo transfer, the fresh embryo transfer can be performed for the woman under her full informed consent, and which can be obtained a certain pregnancy rate, but such fresh embryo transfer for this woman still needs to be thought about carefully.
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