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Abstract To evaluate the predictive value of the levels of placental alpha 1-microglobulin (PAMG-1) and fetal fibronectin (fFN) in the cervical discharge of pregnant women for their spontaneous preterm labor. Methods: The clinical data of 128 pregnant women with spontaneous preterm labor (in study group) from April 2021 to April 2023 were collected, and another 128 normal pregnant women who underwent antenatal examination and delivered at full term were included in control group during the same period. The clinical data and the levels of PAMG-1 and fFN in the cervical discharge of the women were compared between the two groups. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the PAMG-1 and fFN levels of the pregnant women for their spontaneous preterm labor. Results: The predictive accuracy, the positive predictive value and the negative predictive value of the PAMG-1 level of the women for predicting their spontaneous preterm labor were 68.0%, 76.1% and 63.7%, respectively, and which of the fFN level of the women for predicting their spontaneous preterm labor were 67.6%, 73.2% and 64.2%, respectively. The accuracy and the positive predictive value of the combined PAMG-1 and fFN levels of the women for predicting their spontaneous preterm labor were 69.9% and 79.3%, and which were significantly higher than those of the PAMG-1 level and the fFN level (P<0.05). ROC curve analysis showed that the area under the curve, the sensitivity and the specificity of the PAMG-1 level of the women for predicting their spontaneous preterm labor were 0.680, 52.3% and 83.6%, respectively, which of the fFN level of the women for predicting their spontaneous preterm labor were 0.679, 55.5% and 79.7%, respectively, and which of the combined PAMG-1 and fFN levels of the women for predicting their spontaneous preterm labor were 0.699, 53.9% and 85.9%, respectively. Conclusion: The PAMG-1 and fFN levels in the cervical discharge of the pregnant women can be used as the predictors for their spontaneous preterm labor, and the combined PAMG-1 and fFN levels of the women has higher predictive efficiency.
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