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| Value of the levels of hemoglobin, D-dimer and fibrinogen in peripheral blood, and lymphocyte/monocyte ratiovalue of pregnant women with pregnancyinduced hypertension (PIH) for predicting their severity of PIH and adverse pregnancy outcomes |
| Huangshan People's Hospital, Huangshan, Anhui Province, 245000 |
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Abstract To explore the value of the levels of hemoglobin (Hb), D-dimer (D-D) and fibrinogen (Fib)in peripheral blood, and lymphocyte/monocyte ratio (LMR) value of pregnant women with hypertensive disorder complicating pregnancy (PIH) for predicting their severity of PIH and adverse pregnancy outcomes. Methods: 107 pregnant women with PIH from July 2019 to September 2022 were collected in study group retrospectively, including 30 women with gestational hypertension in group A, 40 women with mild preeclampsia in group B and 37 women with severe preeclampsia in group C. In addition, 50 healthy pregnant women who underwent physical examinations during the same period were selected in control group. The differences of the levels of Hb, Fig and D-D, and the LMR value of the women in these groups were analyzed. Receiver operating characteristic (ROC) curve was used to analyze the value of the levels of Hb, Fig and D-D, and the LMR value of the women with PIH for predicting their adverse pregnancy outcomes. Results: The levels of Hb, Fib and D-D, and the LMR value of the women in the study group were significantly higher than those of the women in the control group, and which of the women in group A, in group B and in group C had increased gradually (all P<0.05). Spearman correlation analysis showed that the levels of Hb, Fib and D-D, and the LMR value of the women with PIH were positively correlated with the severity of their PIH (r=0.426, 0.528, 0.388, 0.719, all P<0.05). The incidence of the adverse pregnancy outcomes of the women with PIH increased with the severity of their PIH (P<0.05). ROC curve analysis showed that the areas under the curve of the Hb level, the Fib level, the D-D level, the LMR value, and the combined levels of Hb, Fib and D-D, and the LMR value of the women with PIH for evaluating their adverse pregnancy outcomes were 0.811, 0.890, 0.711, 0.633 and 0.951, respectively. Conclusion: The levels of Hb, Fib and D-D, and the LMR value of the women with PIH are positively correlated with the severity of their PIH, and which have adverse effects on the pregnancy outcomes of the women. The combined levels of Hb, Fib and D-D, and the LMR value of the women with PIH for evaluating their adverse pregnancy outcomes has certain clinical value.
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