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| Anesthesia effect of low-dose esketamine used in laparoscopic uterine fibroid surgery |
| The second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu, Sichuan Province, 610051 |
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Abstract To analyze the anesthesia effect of low-dose esketamine used in laparoscopic uterine fibroid surgery. Methods: 102 patients who wanted laparoscopic uterine fibroids surgery were divided into study group (n=51) and control group (n=51) using a random number table method from January 2022 to December 2023. The anesthesia induction and maintenance methods of the patients in both groups were the same. The patients in the study group received intravenous injection esketamine (0.5mg/kg) before skin incision, followed by continuous intravenous infusion of 0.125mg/(kg·h) of esketamine. The patients in the control group received an equal amount of 0.9% sodium chloride injection at the same time. The anesthesia time, the surgical time, the postoperative recovery time, the extubation time, the VAS pain score at different time points, the Ramsay sedation score, the levels of stress response, such as adrenaline, norepinephrine and cortisol, and the incidence of postoperative adverse reactions of the patients in the two groups were observed and recorded. Results: The VAS scores of the patients in the study group at 6h and 12h after operation (2.01±0.22 points and 2.33±0.36 points) were significantly lower than those (3.25±0.28 points and 3.62±0.47 points) of the patients in the control group. The levels of epinephrine, norepinephrine and cortisol of the patients in the two groups at 24h after operation had increased significantly, but which (69.62±8.54 pg/ml, 198.96±23.29 pg/ml and 290.92±27.19 ng/ml) of the patients in the study group were significantly lower than those (85.52±7.63 pg/ml, 175.60±24.79 pg/ml and 320.25±28.74ng/ml) of the patients in the control group (all P<0.05). There was no significant difference in the total incidence of adverse reactions (19.6% vs. 29.4%) of the patients between the two groups (P>0.05). Conclusion: Low dose esketamine can enhance the postoperative analgesic effect, reduce the postoperative stress reactions and do not increase anesthesia related adverse reactions of the patients, which has certain safety and effectiveness.
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