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| Effect of the combination of remazolam besylate and remifentanil used during hysteroscopic surgery of patients and its influence on the postoperative cognitive function |
| Affiliated Hospital of West Anhui Health Vocational College, Lu’an, Anhui Province, 237001 |
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Abstract To explore the effect of the combination of remazolam besylate and remifentanil used during hysteroscopic surgery of patients, and to study it influence on the postoperative cognitive function of the patients. Methods: 90 patients who wanted hysteroscopic surgery were randomly divided into two groups from December 2021 to December 2023. 45 patients in control group received anesthesia by propofol combined with remifentanil, while 45 patients in observation group received anesthesia by remazolam besylate combined with remifentanil. The anesthesia indicators values, the awakening time, the postoperative pain situation and cognitive function, the levels of serum platelet activating factor (PAF) and Interferon-γ(IFN-γ), and the adverse reactions of the patients in the two groups were observed. Results: The anesthesia induction time (74.3±7.3 s), the dose of remifentanil used (183.3±22.6 μg), the time of breathing recovery (6.2±1.1 min), the extubation time (7.9±1.2 min), the time of eye opening (14.2±2.4 min) and the time of orientation recovery (13.6±2.2 min) of the patients in the observation group were significantly less than those (85.9±6.4s, 211.8±25.9 μg, 8.1±1.3 min, 11.0±2.1 min, 16.7±2.1 min and 16.7±2.4 min) of the patients in the control group. The pain score by VAS of the patients in the observation group at 3h, 6h, 12h and 24h after operation were significantly lower than those of the patients in the control group. The MMSE score of the patients in the observation group at 3h, 6h and 12h after operation (20.45±1.97 points, 24.59±2.20 points and 27.89±1.67 points) were significantly higher than those (18.46±2.05 points, 23.47±2.14 points and 27.24±1.83 points) of the patients in the control group. At 24h after operation, the PAF level of the patients in the two groups had increased significantly and the IFN-γ level of the patients in the two groups had decreased significantly, but the changes of which of the patients in the observation group were significantly less than those of the patients in the control group. The incidence of the adverse reactions (6.7%) of the patients in the observation group was significantly lower than that (22.2%) of the patients in the control group (all P<0.05). Conclusion: The combination of remazolam besylate and remifentanil used during hysteroscopic surgery of the patients has good anesthetic effect, has the advantages of the shorter induction time and faster recovery, can reduce postoperative pain of the patients, has a slight impact on the cognitive function and the serological indicators, and has fewer adverse reactions of the patients, and which it is both effective and safe.
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