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| Correlation between the levels of serum interferon gamma induced protein 10 and sulfhydryloxidase 1 of pregnant women with hepatitis B virus infection and the maternal and infant outcomes |
| First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan Province，453100 |
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Abstract To explore the correlation between the levels of serum interferon gamma induced protein 10 (IP10) and sulfhydryloxidase 1 (QSOX1) of pregnant women with hepatitis B virus (HBV) infection and the maternal and infant outcomes. Methods: 86 pregnant women with HBV infection treated from March 2021 to March 2023 were selected in the study group retrospectively, and 76 normal pregnant women during the same period were selected in the control group. The levels of serum IP10 and QSOX1 detected and the maternal and infant outcomes of the women were recorded and were compared between the two groups. The influencing factors of the maternal and infant outcomes of the pregnant women with HBV infection were explored by multivariate logistic regression model. Receiver operator characteristic (ROC) curve was used to evaluate the diagnostic value of the serum IP10 and QSOX1 levels of the women for their maternal and infant outcomes. Results: The levels of serum IP 10 (68.52±10.46 pg/ml) and QSOX1 (75.62±11.50 ng/ml) of the women in the study group were significantly higher than those (30.22±6.66 pg/ml and 45.25±7.62 ng/ml) of the women in the control group. The incidence of the adverse maternal and infant outcomes (50.0%) of the women in the study group was significantly higher than that (17.1%) of the women in the control group (all P<0.05). Multiple factors logistic stepwise regression analysis showed that the serum IP10 level (OR=1.740, 95% CI 1.403-2.159), the serum QSOX1 level (OR=4.225, 95%CI 2.0508.708) of the women with HBV infection were the main factors affecting their adverse maternal and infant outcomes (P<0.05). ROC curve analysis showed that the area under curve (AUC) of the serum IP10 level, the QSOX1 level, or the combined levels of the IP10 and QSOX1 of the women with HBV infected for evaluating their adverse outcomes of pregnancy were 0.854, 0.867 or 0.925, respectively. Conclusion: The levels of serum IP10 and QSOX1 of the pregnant women with HBV infection increase and the changes of the levels of serum IP10 and QSOX1 were the adverse influence factors of the maternal and infant outcomes, and which can be used as the indicators to evaluating the adverse maternal and infant outcomes of the pregnant women with HBV infection.
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