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Abstract To explore the effect of Bushen Yijing decoction combined with estradiol valerate for treating patients with amenorrhea because of premature ovarian failure (POF), and to study its influence on the sex hormones level and ovary of the patients. Methods: 85 patients with amenorrhea because of POF who treated in hospital were selected and were divided into experimental group (n=43) and control group (n=42) by random number table method from January 2021 to January 2023. The patients in the two groups were treated with estradiol valerate, and the patients in the experimental group were treated with Bushen Yijing decoction additionally. The clinical efficacy, the levels of estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), the sum value of three diameters of uterus, the endometrial thickness, the average ovarian volume, the TCM symptom score and the rate of complications of the patients were compared between the two groups. Results: The total effective rate (86.1%) of the patients in the experimental group was significantly higher than that (66.7%) of the patients in the control group. The levels of serum E2 of the patients in the two groups had increased signifficantly and the levels of FSH and LH of the patients in the two groups had decreased significantly, and the changes of which (93.25±7.56 pmol/L, 14.13±3.04 U/L and 11.24±2.31 U/L) of the patients in the experimental group were significantly more than those (81.25±8.59 pmol/L, 28.54±4.16 U/L and 20.05±2.34 U/L) of the patients in the control group. The sum value of three uterine diameters, the endometrial thickness and the ovarian average volume of the patients in the two groups had increased significantly, and which (27.41±4.14 cm, 8.69±0.99 mm and 35.71±4.81 mm3) of the patients in the experimental group were significantly higher than those (23.52±4.08 cm, 6.93±0.81) mm and 33.10±4.40 mm3) of the patients in the control group. The scores of the vaginal dryness, the decreased sexual desire, the flank swelling pain and the irritability of the patients in the two groups had decreased significantly, and which of the patients in the experimental group were significantly lower than those of the patients in the control group (all P<0.05). The main adverse reactions of the patients during the treatment included mild nausea and vomiting, and breast pain. The total incidence of the adverse reactions (9.3% vs. 7.1%) of the patients had no significant difference between the two groups (P>0.05). Conclusion: Bushen Yijing decoction combined with estradiol valerate for treating the patients with amenorrhea because of POF can increases the clinical effect, which can better improve the sex hormones level and ovary function of the patients.
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