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| Values of the levels of high mobility group A2 and signal transducer and activator of transcription 3 protein of patients with uterine fibroids for evaluating their postoperative recurrence |
| The Second People's Hospital of Yuhang District, Hangzhou, Zhejiang Province, 311121 |
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Abstract To explore the correlation between the levels of high mobility group A2 (HMGA2) and signal transducer and activator of transcription 3 (STAT3) protein of patients with uterine fibroids and their postoperative recurrence of uterine fibroids, and to study the values of the levels of HMGA2 and STAT3 of the patients for evaluating their postoperative recurrence of uterine fibroids. Methods: 168 patients with uterine fibroids who had undergone laparoscopic myomectomy in hospital from May 2019 to December 2020 and were followed up for 3 years after surgery were selected in this study. These patients were divided into group A (48 patients with the postoperative recurrence of uterine fibroids) and group B (120 patients without the postoperative recurrence of uterine fibroids). The general information of the patients was collected. ELISA method was applied to detect the levels of serum progesterone (P), luteinizing hormone (LH), estradiol (E2), follicle stimulating hormone (FSH), and prolactin (PRL) of the patients. Western blot was applied to quantitatively analyze the levels of HMGA2 and STAT3 in the excised uterine fibroids tissues. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic values of the HMGA2 and STAT3 levels of the patients for their postoperative recurrence of uterine fibroids. Multivariate logistic regression was applied to analyze the influencing factors of the postoperative uterine fibroids recurrence of the patients. Results: The levels of serum P, LH, E2, FSH and PRL of the patients in group A were significantly higher than those of the patients in group B. The levels of HMGA2 (1.42±0.28) and STAT3 (1.33±0.24) in the excised uterine fibroids tissues of the patients in group A were significantly higher than those (1.03±0.21, 1.02±0.18) of the patients in group B (all P<0.05). ROC curve analysis showed that the area under the curve (0.934) of the combined levels of HMGA2 STAT3 of the patients for predicting their postoperative uterine fibroids recurrence was significantly higher than that (0.885) of the HMGA2 level and that (0.858) of the STAT3 level (all P<0.05). Multivariate analysis showed that the increase of the preoperative levels of serum P, FSH and PRL, and the postoperative levels of HMGA2 and STAT3 in the excised uterine fibroids tissues of the patients were the influencing factors of their postoperative recurrence of uterine fibroids (all P<0.05). Conclusion: The upregulation of the HMGA2 and STAT3 levels in the excised uterine fibroids tissues of the patients is related to their postoperative recurrence of uterine fibroids. The combined detections of HMGA2 and STAT3 levels of the patients can assist to evaluating the prognosis of the patients in clinic.
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