To explore the correlation between the squamous-cell carcinoma antigen (SCC-Ag) level and neutrophil to lymphocyte ratio (NLR) of women with cervical cancer and their clinicopathological characteristics and prognosis. Methods: 108 women with cervical cancer in group A, 108 women with cervical intraepithelial neoplasia（CIN）in group B and 108 healthy women in group C were enrolled in this study. The levels of SCC-Ag and NLR of the women were compared among the three groups. The correlation between the levels of SCC-Ag and NLR of women in group A and their clinicopathological characteristics and prognosis was analyzed. Results: The levels of serum SCC-Ag and NLR of the women in group A (7.35±1.76 and 4.65±1.06), in group B (2.06±0.53 and 3.41±0.89), and in group C (0.54±0.12 and 1.53±0.34) had decreased gradually (P<0.05). The levels of the serum SCC-Ag and NLR of the women with cervical cancer were related to their pathological type, FIGO stage, pathological grade, depth of myometrial invasion and pelvic lymph node metastasis (P<0.05). Kaplan-Meier showed that the overall survival rate and the disease-free survival rate of the women with the high expressions of SCC-Ag and NLR were significantly lower than those of the women with the low expressions of SCC-Ag and NLR. The overall survival rate and the disease-free survival rate of the women with high expressions of SCC-Ag and NLR were the lowest (all P<0.05). Conclusion: The levels of serum SCC-Ag and NLR of the women with cervical cancer are related to their pathological type, FIGO staging, pathological grading and depth of muscular invasion. The higher of the levels of serum SCC-Ag and NLR, the worse of the prognosis of the women.