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| Comparison of the anesthetic effect of esketamine combined with propofol and sufentanil combined with propofol used during painless abortion |
| The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052 |
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Abstract To compare the anesthetic effect of esketamine combined with propofol and sufentanil combined with propofol used during painless abortion. Methods: A total of 102 women who wanted painless abortion were divided into two groups (51 cases in each group) according to random number table method from February 2023 to October 2023. The women in group A were given sufentanil 0.1μg/kg combined with propofol 2.0mg/kg for anesthesia during painless abortion, and the women in group B were given esketamine 0.2mg/kg combined with propofol 2.0mg/kg for anesthesia during painless abortion. The values of hemodynamic indexes, perioperative indexes, pain degree of contraction after recovery and the occurrence of adverse reactions of the women were compared between the two groups at different time points ［before anesthesia induction (T0), at 1min after administration (T1), at 3min after administration (T2), when consciousness disappeared (T3), at the beginning of surgery (T4), at the end of surgery (T5)］. Results: The values of diastolic blood pressure, systolic blood pressure, mean arterial pressure and heart rate of the women in group B at T3, T4 and T5 were significantly higher than those of the women in group A, and the blood oxygen saturation value of the women in group B at T4 was significantly higher than that of the women in group A. The total dosage of propofol (121.33±12.48mg/kg) and the time of loss of consciousness (32.59±3.87s) of the women in group B were significantly lower than those (150.49±14.26mg/kg and 37.06±4.52s) of the women in group A. The score of visual analogue scale (VAS) of the women in group B at 15 minutes (2.75±0.36 points) and at 30 minutes (3.15±1.02 points) after awakening were significantly lower than those (3.69±0.58 points and 4.48±1.59 points) of the women in group A, and the incidence of adverse reactions (13.7%) of the women in group B was significantly lower than that (31.4%) of the women in group A (all P<0.05). Conclusion: Esketamine combined with propofol used during the painless abortion of the women has better anesthetic effect than that of sufentanil combined with propofol used, which can effectively maintain the hemodynamic stability, reduce the dosage of propofol and the degree of pain because of uterine contraction after abortion of the women, and with less adverse reaction and higher safety.
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