|
|
|
| Analysis of the perinatal birth defects monitoring results in two counties of Jiangsu province from 2011 to 2021 |
| 1. National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention, Beijing, 100081; 2. Institute of Population Research, Peking University; 3. Jiangsu Women and Children Health Hospital |
|
|
|
|
Abstract To explore the occurrence of the perinatal birth defects incidences and their trends in Jinhu county and Xuyi county of Jiangsu province from 2011 to 2021. Methods: A cross-sectional study was conducted using the data of the Birth and Birth Defects Monitoring Project spanning from 2011 to 2021, and a Joinpoint regression model was applied to analyze the changing trend of the incidence of birth defects. The annual percentage change (APC) in each time period and the average annual percentage change (AAPC) in the overall time period of the perinatal birth defects were calculated. Results: From 2011 to 2021, the incidence of the perinatal birth defects (341.3 per 10 000) in Jinhu County was significantly higher than that (212.8 per 10 000) in Xuyi County. The incidence of the perinatal birth defects in Jinhu county showed an upward trend (AAPC=8.6%, P<0.05), and the birth defects in Jinhu county had increased rapidly during 2017-2021 (APC=20.4%, P<0.05). The time trend was not found in the incidence of the perinatal birth defects in Xuyi county. The incidence of the perinatal birth defects of the males was significantly higher than that of the females, and which of the babies with the advanced maternal and paternal age was significantly higher than that of the babies with the appropriate maternal and paternal age. The top five birth defects in Jinhu county were the congenital heart disease (144.4 per 10 000), the umbilical hernia (51.2 per 10 000), the polydactyly (28.7 per 10 000), the other malformations of the external ear (11.6 per 10 000) and the other malformations of the digestive system (8.8 per 10 000). The top five birth defects in Xuyi county were the congenital heart disease (74.9 per 10 000), the other malformations of the external ear (17.8 per 10 000), the polydactyly (16.2 per 10 000), the umbilical hernia (10.5 per 10 000) and the inguinal hernia (9.0 per 10 000). Conclusion: From 2011 to 2021, the incidence of the birth defects in Jinhu county showed an upward trend and the rate of the increased of which has accelerated from 2017 to 2021 significantly, however, the time trend is not found in the incidence of the birth defects in Xuyi county. The congenital heart disease is the most common birth defect in both counties, and the higher incidence of the umbilical hernia is found in Jinhu county. It is suggested that the systematic health care should be provided to the parents with advanced age before pregnancy, during pregnancy and delivery in order to reduce the incidence of the birth defects.
|
|
|
|
|
|
|
|
|
