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| Values of the levels of micro-ribonucleic acid 182, tumor necrosis factor- α and S100 calcium binding protein B in umbilical cord blood and in amniotic fluid of pregnant women for predicting the brain injury of their preterm infants |
| Cangzhou Maternal and Child Health Care Hospital, Cangzhou, Hebei Province, 061001 |
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Abstract To evaluate the clinical value of the levels of micro-ribonucleic acid 182 (miR-182), tumor necrosis factor- α (TNF-α) and S100 calcium binding protein B (S100B) in umbilical cord blood and in amniotic fluid of pregnant women for predicting the brain injury of their preterm infants. Methods: The clinical data of 104 pregnant women with premature rupture of membranes and intrauterine infection from June 2021 to June 2023 were selected in this study. The gestational age at delivered of the preterm infants were less than 34 gestational weeks. The head imaging examination was performed for the infants of 104 women. Based on the infants brain injury occurrence or not, these women were divided into group A (36 women with the brain injury of their infants) and group B (68 women without the brain injury of their infants). The levels of miR-182, TNF-α and S100B proteins in maternal umbilical cord blood and in amniotic fluid of the women were detected and were compared between two groups. Receiver operating characteristic (ROC) curve was used to evaluate the values of the levels of miR-182, TNF-α and S100B proteins in maternal umbilical cord blood and in amniotic fluid of the women with premature rupture of membranes and intrauterine infection for predicting the brain injury of their infants. Results: The levels of the miR-182, TNF-α and S100B protein in cord blood of the women in group A were significantly higher than those of the women in group B, and the levels of the miR-182 and TNF-α in amniotic fluid of the women in group A were also significantly higher than those of the women in group B (all P<0.05). There was no significant difference in the S100B protein level in amniotic fluid of the women between the two groups (P>0.05). ROC curve analysis showed that the area under the curve (AUC) of the miR-182 level, the TNF-α level or the S100B protein level in cord blood of the women for predicting the brain injury of their preterm infants was 0.816, 0.748 or 0.697, respectively. The sensitivity of which was 72.2%, 66.7% or 55.6%, and the specificity of which was 83.8%, 77.9% or 88.2%, respectively. The AUC of the miR-182 level, the TNF-α level or the S100B protein level in amniotic fluid of the women for predicting the brain injury of their preterm infants was 0.713, 0.689 or 0.594, respectively, the sensitivity of which was 63.9%, 55.6% or 30.6%, and the specificity of which was 86.8%, 85.3% or 86.8%, respectively. Conclusion: The levels of the miR-182, TNF-α and S100B protein in cord blood and in amniotic fluid of the women with premature rupture of membranes and intrauterine infection have certain values for predicting the brain injury of their preterm infants.
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