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| Levels of mannan-binding lectin-associated protein 19, osteopontin and pregradient protein 2 of patients with cervical cancer before operation and their predictive values for the recurrence within 2 years after operation |
| West Branch of Qingdao Municipal Hospital，Qingdao，Shandong Province, 266100 |
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Abstract To explore the risk factors of the recurrence of cervical cancer of patients, and to study the predictive values of the levels of mannan-binding lectin-associated protein 19 (MAP19), osteopontin (OPN), and pregradient protein 2 (AGR2) of patients for their recurrence of cervical cancer. Methods: The clinical data of 250 patients with cervical cancer treated in hospital from January 2016 to January 2021 were collected in this study. Based on the recurrence of cervical cancer or not in the 2 years of follow up after operation, these patients were divided in 32 cases with the recurrence of cervical cancer in group A and 218 cases without the recurrence of cervical cancer in group B. The risk factors of the postoperative cervical cancer recurrence of the patients were analyzed. The levels of serum MAP19, OPN and AGR2 of the patients in the two groups were detected. Receiver operator characteristic (ROC) curve was used to analyze the values of the serum MAP19, OPN and AGR2 levels of the patients for predicting their postoperative recurrence of cervical cancer. Results: There were significant differences in the diameter, the differentiation degree of tumor, the tumor stromal invasion, the tumor FIGO stage and the lymph node metastasis of the patients between the two groups. The levels of serum MAP19 (266.04±80.21μg/L), OPN (61.25±20.14μg/L) and AGR2 (12.44±3.14 ng/ml) of the patients in group A were significantly higher than those (138.25±56.73μg/L, 19.45±3.56μg/L and 12.44±3.14 ng/ml) of the patients in group B. Multivariate unconditional logistic analysis showed that the tumor diameter ≥4 cm, the high degree of tumor differentiation, the deep muscular invasion of tumor, the FIGO stage IA1-IA2, the lymph node metastasis, and the high levels of MAP19, OPN and AGR2 of the patients were the independent risk factors of their postoperative recurrence of cervical cancer (all P<0.05). ROC analysis showed that the area under the curve (AUC), the sensitivity, the specificity and the cut-off value of the serum MAP19 level of the patients for predicting their postoperative recurrence of cervical cancer were 0.702, 73.2%, 80.1% and 186.54μg/L, respectively. The AUC, the sensitivity, the specificity and the cut-off value of the serum OPN level of the patients for predicting their postoperative recurrence of cervical cancer were 0.825, 76.4%, 82.5% and 34.76μg/L, respectively. The AUC, the sensitivity, the specificity and the cut-off value of the serum AGR2 level of the patients for predicting their postoperative recurrence of cervical cancer were 0.727, 74.6%, 79.8% and 7.46ng/ml, respectively. Conclusion: The levels of serum MAP19, OPN and AGR2 of the patients with postoperative recurrence of cervical cancer increase abnormally, which are the independent risk factors for the postoperative recurrence of cervical cancer of the patients, and which have certain reference values for predicting the recurrence of cervical cancer of the patients within 2 years after surgery.
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