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| Predictive values of the serum betatrophin and angiopoietin like protein 4 levels of pregnant women with gestational diabetes mellitus for their pregnancy outcomes |
| Shiyan Maternal and Child Health Care Hospital, Shiyan, Hubei Province, 442000 |
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Abstract To explore the value of the combined levels of betatrophin and angiopoietin like protein 4 (ANGPTL4) of pregnant women with gestational diabetes mellitus (GDM) for predicting their pregnancy outcomes. Methods: A total of 128 pregnant women with GDM delivered in hospital from October 2019 to September 2022 were collected in study group retrospectively, 128 healthy pregnant women who delivered in hospital were collected in control group during the same period. The serum betaprophin and ANGPTL4 levels, and the pregnancy outcomes of the women were compared between the two groups. The influencing factors of the adverse pregnancy outcomes of the women in the study group were analyzed by logistic regression analysis. The predictive values of the levels of serum Betaprophin and ANGPTL4 of the women with GDM for their pregnancy outcomes were analyzed by receiver operator characteristic (ROC) curve. Results: The serum betatrophin level (390.27±65.05 pg/ml) and the incidence of adverse pregnancy outcomes (34.4%) of the women in the study group were significantly higher than those (291.56±48.59 pg/ml and 8.6%) of the women in the control group. The level of ANGPTL4 (4.23±1.40 ng/ml) of the women in the study group was significantly lower than that (8.22±2.74 ng/ml) of the women in the control group. The proportion of the family history of diabetes and the serum betatrophin level of the women with GDM and adverse pregnancy outcomes were significantly higher than those of the women with GDM and normal pregnancy outcomes, and the level of ANGPTL4 of the women with GDM and adverse pregnancy outcomes was significantly lower. The family history of diabetes, the higher betatrophin level and the lower ANGPTL4 level of the women with GDM were the risk factors of their adverse pregnancy outcomes (all P<0.05). The area under the curve (AUC) of the serum betatrophin level and the ANGPTL4 level of the women with GDM for predicting their adverse pregnancy outcomes were 0.864 and 0.877. The AUC, the sensitivity and the specificity of the combined levels of betatrophin and ANGPTL4 of the women with GDM for predicting their adverse pregnancy outcomes were 0.968, 97.7% and 85.7%, respectively. Conclusion: The level of serum betaprophin of the women with GDM is higher and the level of serum ANGPTL4 is lower, and both of which are the risk factors of the adverse pregnancy outcomes of the women. The combined levels of betatrophin and ANGPTL4 of the women with GDM has better value for predicting their pregnancy outcomes.
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