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| Analgesia effect of the different dosages of lidocaine combined with propofol for the intravenous anesthesia during induced abortion and its influence on the postoperative recovery of women |
| Xiuzhou District Maternity and Child Health Care Hospital of Jiaxing, Jiaxing, Zhejiang Province, 314031 |
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Abstract To explore the effect and safety of the different dosages of lidocaine combined with propofol for the intravenous anesthesia during induced abortion of women. Methods: 100 women who planned to undergo induced abortion were selected as research objects from January 2021 to January 2023. According to the numerical table method, these women were randomly divided into two groups (50 cases in each group). The women in group A were given propofol combined with 2% lidocaine for intravenous anesthesia during abortion and the women in group B were given propofol combined with 1% lidocaine for intravenous anesthesia. The anesthetic effect, the pain score of VAS, the hemodynamics, the inflammatory factors levels and the incidence of the adverse reactions of the women were compared between the two groups. Results: The time of the conscious recovery (4.7±0.8 min) and the time of the orientation recovery (6.1±0.6 min) of the women in group B were significantly shorter than those (9.1±0.6 min and 10.6±1.0 min) of the women in group A. The operation time (12.4±0.4 min) and the dosage of propofol (106.6±3.4 mg) of the women in group B were significantly higher than those (10.2±0.6 min and 97.9±1.3 mg) of the women in group A (P<0.05). The values of the mean arterial pressure (MAP) and heart rate (HR) during waking of the women in the two groups had increased significantly, but which (80.3±1.5 mmHg and 82.8±1.2 beats /min) of the women in group A were significantly lower than those (84.7±1.7 mmHg and 86.3±0.8 beats /min) of the women in group B. The VAS scores of the women in the two groups at 30min after abortion had decreased significantly, and the MAP and HR values of the women in of the two groups at 30min after abortion were significantly higher than those before anesthesia. The MAP and HR values of the women in group A were significantly lower than those of the women in group B. The TNF-αand IL-6 levels of the women in the two groups at 10min after abortion had increased significantly, and which (34.35±3.11 pg/ml and 24.93±2.65 pg/ml) of the women in group A were significantly lower than those (50.25±2.95 pg/ml and 50.50±2.74 pg/ml) of the women in group B (all P<0.05). There was no significant difference in the incidence of the adverse reactions (26.0% vs.12.0%) of the women between the two groups (P>0.05). Conclusion: 2% lidocaine combined with propofol for the intravenous anesthesia during induced abortion of the women can improve their analgesic effect, and which can help to shorten the operation time and increase the amount of propofol uased of the women, reduce the influence of the surgical anesthesia on the hemodynamics and inflammation of the women. 1% lidocaine combined with propofol for the intravenous anesthesia during induced abortion of the women can help to promote their recovery of consciousness and orientation, and the incidences of respiratory depression, nausea and vomiting, dizziness and other side effect of the women are less, with the higher safety.
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