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Abstract To analysis of the values of the uterine artery flow parameters by Doppler ultrasonography and the levels of serum pro-angiogenic factor (PIGF), serine protease inhibitor (Vaspin) and endothelial cell specific molecule-1 (ESM-1) of pregnant women, and to study their diagnostic values for the hypertensive disorder of pregnancy (HDP) of the pregnant women. Methods: 86 pregnant women with HDP from June 2020 to December 2021 were collected in study group retrospectively, and 75 healthy pregnant women were selected in control group. The levels of the serum PIGF, Vaspin and ESM-1, and the uterine artery blood flow parameters of the women in the two groups were detected, and the values of which for diagnosing HDP of the women were analyzed. Results: The serum level of PIGF (271.56±45.56 pg/ml) of the women in the study group was significantly lower than that (330.15±50.35 pg/ml) of the women in the control group. The levels of Vaspin (0.46±0.04 ng/ml) and ESM-1(1.38±0.51μg/L) of the women in the study group were significantly higher than those (0.39±0.08) ng/ml and 1.01±0.07μg/L) of the women in the control group. The values of uterine artery resistance index (RI, 0.79±0.14), pulsatility index (PI, 0.83±0.21), and the ratio of peak systolic velocity to end diastolic velocity (S/D, 2.26±0.74) of the women in the study group were significantly higher than those (0.51±0.20, 0.44±0.19 and 1.41±0.35) of the women in the control group. In the study group, there were significant differences in the levels of PIGF, Vaspin and ESM-1, and the values of RI, PI and S/D among the women with HDP, the women with mild preeclampsia and the women with severe preeclampsia (all P<0.05). Receiver operating characteristic curve analysis showed that the area under the curve of the serum PIGF level, the serum Vaspin level, the serum ESM-1 level, and the RI value, the PI value, the S/D value, and the combination of the levels of PIGF, Vaspin and ESM-1, and the values of RI, PI and S/D of the women for the diagnosing their HDP were 0.811, 0.780, 0.691, 0.944, 0.860, 0.813 and 0.999, respectively, the cut-off values of which were 291.56 pg/ml, 0.43 ng/ml, 1.12μg/L, 0.58, 0.53 and 1.87, respectively. The specificity and the accuracy of the combination of the levels of PIGF, Vaspin and ESM-1, and the values of RI, PI and S/D of the women for diagnosing their HDP were the highest, which were 96.5% and 93.4% (all P<0.05). Conclusion: The levels of the serum PIGF, Vaspin and ESM1, and the uterine artery blood flow parameters of the pregnant women with HDP are abnormal, and which have better diagnostic values for HDP of the women, and this study also provides a new idea for treating HDP by the targeted drugs.
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