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| Correlation between the levels of serum microrNA 26b and microrNA 320b of pregnant women with gestational diabetes mellitus and their insulin resistance |
| Changzhou Maternal and Child Health Care Hospital, Changzhou, Jiangsu Province, 213000 |
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Abstract To analyze the correlation between the levels of serum microrNA (miR) 26b and miR 320b of pregnant women with gestational diabetes mellitus (GDM) and their insulin resistance (IR). Methods: A total of 85 pregnant women with GDM admitted to hospital from May 2020 to May 2023 were selected in study group retrospectively, and 90 healthy pregnant women who underwent prenatal examination were selected in control group during the same period. The levels of serum miR 26b and miR 320b of the women in the two groups were detected. The clinical data of the women were collected and were compared between the two groups. Pearson method was used to analyze the correlation between the miR 26b and miR 320b levels of the women with GDM and their IR. According to whether the women with IR or not, the women in the study group were divided into group A (women with IR) and group B (women without IR). The influencing factors of the IR occurrence of the women with GDM were analyzed by univariate and multivariate factors. Results: There were no significant differences in the age, the gestational weeks at delivery, the delivery history, and the values of systolic blood pressure and diastolic blood pressure of the women between the study group and the control group (P＞0.05). The values of the pregnancy body mass index (BMI) and the homeostasis model assessment of insulin resistance (HOMA-IR) of the women in the study group were significantly higher than those of the women in the control group, and the levels of miR 26b and miR 320b of the women in the study group were significantly lower than those of the women in the control group (all P＜0.05). The levels of miR 26b and miR 320b of the women in the study group were negatively correlated with their HOMA-IR value (P＜0.05), with the IR incidence of 61.7%. The BMI value, and the levels of glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) and fasting insulin (FINS) of the pregnant women with IR were significantly higher than those of the pregnant women without IR, and the levels of miR 26b and miR 320b of the pregnant women with IR were significantly lower (all P＜0.05). Logistic regression analysis showed that the miR 26b level (OR=0.305) and the miR 320b level (OR=0.426) of the women with GDM were the independent protection factor of their IR occurrence (all P＜0.05). ROC curve analysis showed that the sensitivity of the miR 26b level, the miR 320b level, and the combined miR 26b and miR 320b levels of the women with GDM for predicting their IR occurrence were 73.9%, 69.6% and 87.0%, respectively, the specificity of which were 66.2%, 71.6% and 87.8%, respectively, and the area under the curve of which were 0.778, 0.798 and 0.918, respectively. Conclusion: The expressions of miR 26b and miR 320b of the pregnant women with GDM are abnormally low, and which are negatively correlated with their HOMA-IR value. The increases of the miR 26b and miR 320b levels of the pregnant women with GDM are the protective factors of their IR occurrence. The combined detection of the miR 26b and miR 320b levels of the pregnant women with GDM can effectively predict their IR occurrence.
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