To investigate the effects of carboprost methyl pessary combined with hysteronin for treating women with caesarean section on their coagulation function, haemoglobin (HB) level and postpartum haemorrhage. Methods: 145 women who had undergone cesarean section from July 2022 to October 2023 were selected in this study retrospectively. These women were divided into 72 cases treated with contractions in control group and 73 cases treated with carproterone suppositories combined with contractions in experimental group according to the different treatments. The values of the coagulation function, such as prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), D-dimer (D-D) and fibrinogen (FIB), before and after treatment, the values of the hemodynamic changes, such as blood oxygen saturation, HB, systolic blood pressure (SBP), diastolic blood pressure (DBP), the postpartum blood loss at different time points and the adverse reactions rate after treatment of the women were compared between the two groups. Results: The levels of APTT, PT, and TT of the women in the experimental group after treatment were significantly lower than those of the women in the control group, and the levels of FIB and D-D of the women in the experimental group after treatment were significantly higher (P<0.05). There were no significant differences in the values of the blood oxygen saturation, SBP and DBP of the women between the two groups (P>0.05). The HB level of the women in the experimental group was significantly higher than that of the women in the control group (P<0.05). The amount of bleeding of the women in the experimental group at 2h (143.44±19.35 ml), at 12h (248.74±22.72 ml) or at 24h (328.41±39.96 ml) after delivery was significantly lower than that (249.37±30.48 ml, 331.69±35.88 ml or 497.74±41.18 ml) of the women in the control group. The total incidence of the adverse reactions (6.9%) of the women in the experimental group was significantly lower than that (19.4%) of the women in the control group (all P<0.05). Conclusion: Carboprost suppositories combined with oxytocin for treating the women after cesarean section can significantly reduce their postpartum haemorrhage, improve their coagulation, increase their HB level, and with the reliable medication safety.