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| Effects of the different doses of nalbuphine combined with lidocaine for anesthesia of women during cesarean section on their anesthetic effect, recovery quality and stress response |
| 1.Linquan County People's Hospital, Linquan, Anhui Province, 236400；2.Fuyang People's Hospital, Fuyang, Anhui Province |
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Abstract To analyze the anesthetic effect and safety of the different doses of nalbuphine combined with lidocaine for anesthesia of women during cesarean section. Methods: A total of 82 women who wanted cesarean section admitted to the hospital were selected and were divided into two groups by random method from February 2021 to April 2024. During cesarean section, the women in group A were given 0.1mg/kg nalbuphine combined with lidocaine for anesthesia and the women in group B were given 0.2mg/kg nalbuphine combined with lidocaine for anesthesia. The anesthesia effect evaluated by visual analogue scale (VAS) of uterine contraction pain and the analgesic duration, the quality of recovery, such as the first time of getting out of bed, the anal vent time, the lactation onset time and the number of lactation within 48h after cesarean section, the situation stress response, such as the levels of serum cortisol (Cor), norepinephrine(NE) and zymosterone, and the postoperative complication rate of the women were compared between the two groups. Results: The VAS score (2.06±0.19 points) of the women in group A was significantly lower than that (3.65±0.24 points) of the women in group B. The duration of analgesia (4.15±0.41 h) of the women in group A was significantly higher than that (3.89±0.62 h) of the women in group B. The first time of getting out of bed (13.4±2.3h), the anal exhaust time (21.4±5.3h) and the lactation start time (24.4±5.4h) of the women in group A were significantly shorter than those (14.8±3.7h, 23.9±4.8h and 29.5±5.8h) of the women in group B. The number of the lactation (8.2±1.6 times) of the women in group A within 48 hours after cesarean section was significantly higher than that (6.4±1.5 times) of the women in group B. The serum levels of Cor, NE and ALD of the women in group A were significantly lower than those of the women in group B. The total incidence (14.6%) of complications of the women in group A was significantly lower than that (36.6%) of the women in group B (all P<0.05). Conclusion: The application of the low dose nalbuphine combined with the lidocaine for anesthesia of the women during cesarean section can improve the anesthetic effect, accelerate the postoperative recovery and reduce the stress response of the women, and with the higher safety.
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