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| Investigation of the feeding intolerance of premature infants and its related factors analysis and prevention suggestions |
| The First Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325015 |
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Abstract To explore the feeding intolerance status of premature infants, to analyze the related factors and to propose the prevention strategies of the feeding intolerance of the infants. Methods: The medical records of 115 premature infants admitted to the hospital from January 2021 to December 2023 were analyzed retrospectively. According to the presence or absence of the feeding intolerance of the infants, these infants were divided into group A (71 cases with the feeding tolerance) and group B (44 cases with the feeding intolerance). The clinical data and the influencing factors of the feeding intolerance of the premature infants in the two groups were analyzed. Results: Among the 115 preterm infants, the incidence of the feeding intolerance was 38.3%. The proportions of the intrauterine distress, the birth asphyxia, the bronchopulmonary dysplasia, the positive pressure respiratory support >24 hours and the caffeine citrate injection, the initial feeding time, the meconium exhaustion time and the amount of the iatrogenic blood collection within one week after birth of the premature infants in group A were significantly lower than those of the premature infants in group B, while the duration of the non-nutritional sucking of the premature infants in group A was significantly higher (all P<0.05). There were no significant differences in the gender, the gestational weeks at birth, the birth weight, the Apgar score at 1 min after birth, the polyembryony, the delivery mode, and the rates of the placental abnormality and the intrauterine infection, the intravenous nutrition time and the kangaroo mother care time of the premature infants between the two groups (P>0.05). Multivariate logistic regression analysis showed that the intrauterine distress (OR=2.344), the birth asphyxia (OR=2.433), the bronchopulmonary dysplasia (OR=2.123), the duration of the positive pressure respiratory support (OR=2.524), the delayed initial feeding (OR=2.008), the longtime of meconium excretion (OR=2.248), the caffeine citrate injection (OR=2.396), the large amount of iatrogenic blood collection within one week after birth (OR=2.109) and the short duration of non-nutritive sucking (OR=2.366) of the premature infants were all the independent factors influencing their feeding intolerance (all P<0.05). Conclusion: The effective intervention measures based on the possible influencing factors of the feeding intolerance of the premature infants should be conducted in clinic timely, so as to improve the feeding status and to promote the growth and development of the premature infants.
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