|
|
|
| Correlation between the serum 25-hydroxyvitamin D level of women with gestational diabetes mellitus and their levels of C-reactive protein, pentamer protein 3 and amyloid P |
| Lianyungang Hospital Affiliated to Xuzhou Medical University (Lianyungang First People's Hospital), Lianyungang, Jiangsu Province, 222000 |
|
|
|
|
Abstract To investigate the correlation between the serum 25-hydroxyvitamin D level of pregnant women with gestational diabetes mellitus (GDM) and their levels of Creactive protein (CRP), pentamer protein 3 (PTX3) and amyloid P (SAP). Methods: 100 pregnant women with GDM during the second trimester of pregnancy (24-28 gestational weeks) were included in observation group, and 100 healthy pregnant women were selected in control group from January 2022 to June 2023. The women in the two groups were followed up to the third trimester of pregnancy (31-38 gestational weeks). The changes of the levels of the serum 25(OH)D, CRP, PTX3, SAP and the glucose metabolism indexes of the women in the two groups during the second and the third trimester of pregnancy were observed. Pearson correlation was used to analyze the correlation among the levels of the serum 25(OH)D, CRP, PTX3, SAP and the glucose metabolism indexes of the women. Results: The serum 25(OH)D levels in the second and in third trimester of pregnancy (21.75±8.20 mmol/L and 20.88±4.36 mmol/L) of the women in the observation group were significantly lower than those (24.25±8.84 mmol/L and 22.75±8.21 mmol/L) of the women in the control group. The levels of high-sensitivity C-reactive protein (Hs-CRP), SAP, PTX3, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) of the women in the observation group were significantly higher than those of the women in the control group. The levels of the fasting plasma glucose (FPG), fasting insulin (FINS), and the value of the insulin resistance index of homeostasis model assessment of insulin resistance (HOMA-IR) of the women in the observation group were significantly higher than those of the women in the control group (all P<0.05). Pearson correlation analysis showed that the serum 25(OH)D levels of the women in the observation group during the second and the third trimester of pregnancy were negatively correlated with their Hs-CRP, PTX3, FPG, FINS, HOMA-IR and IL-6 levels (P<0.05), but which were not correlated with their SAP and TNF-αlevels (P>0.05). The levels of the Hs-CRP, TNF-α, PTX3 and IL-6 of the women in the observation group during the second and the third trimester of pregnancy were positively correlated with their FPG and FINS levels, and their HOMA-IR value (all P<0.05), while the SAP level of the women was not correlated with their FPG and FINS levels, and their HOMA-IR value (P>0.05). Conclusion: The level of serum 25(OH)D of the pregnant women with GDM is low, and which is negatively correlated with the levels of Hs-CRP, PTX3 and IL-6 of the women, and was positively correlated with the insulin resistance of the women, and which has no significant correlation with the SAP level of the women.
|
|
|
|
|
|
|
|
|
