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| Correlation between the Down syndrome screening indexes and the hemorheological indexes women and their hypertensive disorder complicating pregnancy |
| 1.Hangzhou Maternal and Child Health Hospital, Hangzhou, Zhejiang Province, 310012；2.Hangzhou Obstetrics and Gynecology Hospital, Hangzhou |
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Abstract To analyze the risk factors of the hypertensive disorder complicating pregnancy (HDP) of pregnant women based on their indexes of Down's screening and hemorheology. Methods: 80 pregnant women with HDP admitted to the hospital from January 2020 to December 2023 were selected in study group retrospectively, another 76 pregnant women without HDP who had received antenatal examination were selected in control group. The indexes of Down's screening and hemorheology of the women were compared between the two groups. Univariate and logistic multivariate regression analysis were used to analyze the risk factors of HDP of the women. Spearman rank correlation analysis was used to analyze the correlation between the indexes of Down's screening and hemorheology of the pregnant women and their HDP occurrence. Results: There were significant differences in the obesity rate, the history of diabetes, the family history of HDP, the prenatal examination situation, the negative emotions, the values of activated partial prothrombin time (APTT), prothrombin time (PT), thrombin time (TT) and pregnancy-associated plasma protein A (PAPP-A), and the levels of β-human chorionic gonadotropin (β-hCG), free estriol (uE3) and alpha fetoprotein (AFP) the women were compared between the two groups (P<0.05). Multivariate analysis showed that the obesity, the history of diabetes, the family history of HDP, the lack of regular prenatal examination, the negative emotions, the decreased values of APTT, PT, TT, uE3, and PAPP-A, and the increased levels of AFP and β-hCG of the women were the independent risk factors of their HDP occurrence (all P<0.05). Spearman correlation analysis showed that the levels of APTT, PT, TT, uE3 and PAPP-A of the women were negatively correlated with their HDP occurrence (r=-0.438, -0.452, -0.434, 0.478, -0.423, all P<0.05). The levels of AFP and β-hCG of the women were positively correlated with their HDP occurrence (r=0.463, 0.441, all P<0.05). Conclusion: The Down syndrome screening indicators, such as serum uE3, AFP, PAPP-A andβ-hCG, and the hemorheological indicators, such as APTT, PT and TT of the pregnant women are all closely related to their HDP occurrence, and all of which should be paid attention to in clinical prenatal examination, and the corresponding prevention and treatment measures should be conducted to reduce the risk of HDP and to improve the pregnancy outcomes of the women.
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