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| Value of P16 and Ki-67 detections for diagnosing cervical squamous intraepithelial lesions and the correlation between the P16 and Ki-67 detections and human papillomavirus infection |
| Wuzhou Red Cross Hospital，Wuzhou, Guangxi Zhuang Autonomous Region, 543002 |
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Abstract To investigate the value of P16 and Ki-67 detections of patients for diagnosing their cervical squamous intraepithelial lesions, and to study the correlation between the P16 and Ki-67 detections of the patients and their human papillomavirus (HPV) infection. Methods: 150 women diagnosed with cervical squamous intraepithelial lesions according to the results of the colposcopy and the histopathological examination as the gold standard who treated in the hospital were selected in study group, and 150 healthy women were selected in control group from February 2022 to February 2024. The positive expressions of P16 and Ki67 of the women were detected by Thinprep cytologic test (TCT) and the HPV DNA. Receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic values of P16 and Ki-67 of the women for their cervical squamous intraepithelial lesions. Spearman correlation coefficient was used to analyze the correlation between the P16, Ki-67 positive expressions of the women and their HPV infection. Results: The positive expression rates of P16 (94.7%) and Ki67 (93.3%) of the women in the study group were significantly higher than those (3.3% and 5.3%) of the women in the control group (P<0.05). ROC curve analysis showed that the area under the curve of the P16 and Ki-67 positive expressions of the women for diagnosing their cervical squamous intraepithelial lesions were 0.957 and 0.940, the sensitivity of which were 94.7% and 93.3%, and the specificity of which were 96.7% and 94.7%. The positive expressions of the P16 and Ki-67 positive expressions of the women with cervical squamous intraepithelial lesions were positively correlated with their HPV infection (r=0.705, 0.726, all P<0.05). Conclusion: The positive expressions of P16 and Ki-67 of the women with cervical squamous intraepithelial lesions increase abnormally, and which are positively correlated with the HPV infection of the women, and both of them have the higher diagnostic value for the cervical squamous intraepithelial lesions of the women.
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